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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
CI-978; AT-4140
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
110871-86-8
- 规格：
100 mg/500 mg
| 规格： | 100 mg | 产品价格： | ￥450.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥960.0 |
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Sparfloxacin
CAS No. : 110871-86-8
MCE 国际站：Sparfloxacin
产品活性：Sparfloxacin (CI-978) 是氟喹诺酮类抗菌素。
研究领域：Anti-infection
作用靶点：Bacterial | Antibiotic
In Vitro: Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis.
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文献和实验代头孢菌素，碳青霉素烯类(Carbapenems)的亚胺培南(Imipenem)、美罗培南((Meropenem)、帕尼培南(Panipenem)等。常用的氟喹诺酮类如氧氟沙星、环丙沙星对肺炎链球菌作用不佳，而较新品种如托氟沙星(Tosufloxacin)、克林沙星(Clinafloxacin)、司氟沙星(Sparfloxacin)对耐药肺炎链球菌有效，便用于PRSP所致的LRT1尚待积累临床资料。另一些新的糖肽类抗生素、酮内酯类(Ketolides)、链阳菌素类等对多重耐药肺炎链球菌也显示了较好疗效
O.Postantbiotic Sub-MIC Effects Vancomycin,Roxithromycin,Sparfloxacin,and Amikacin[J]. Antimicrob. Agents Chemother.,1992,36(9)：1852~1858 14 . Jacobs MR.Pharmacodynamic Breakpoints：New Concepts for Old Problems.ISAAR2001：178-186 摘自
活性。口服吸收率达99%。体内分布广，主要经肾排泄，t1/2为9~13 h，可每日给药一次。主要用于治疗敏感菌所致的呼吸系统、泌尿生殖系统、胃肠道及皮肤软组织感染。 Sparfloxacin（又称司氟沙星，斯帕沙星）具有强大的组织穿透力，可迅速进入多种组织和体液。t1/2约17 h，可每天给药一次。对葡萄球菌和链球菌等革兰阳性球菌的作用强。对肠杆菌科和绿脓杆菌的体外活性不如ciprofloxacin，但体内疗效却优于ciprofloxacin，且对这两种细菌的抗菌活性均强于
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