- ￥174 - 3534
- MedChemExpress(MCE)
- 美国
- HY-B0233
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
PN 200-110
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
75695-93-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥614.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥174.0 |
| 规格： | 5 mg | 产品价格： | ￥348.0 |
| 规格： | 10 mg | 产品价格： | ￥558.0 |
| 规格： | 50 mg | 产品价格： | ￥2046.0 |
| 规格： | 100 mg | 产品价格： | ￥3534.0 |
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Isradipine
CAS No. : 75695-93-1
MCE 国际站：Isradipine
产品活性：Isradipine (PN 200-110) 是一个具有口服活性的 L 型钙通道阻滞剂。Isradipine 是一种强效外周血管扩张剂，是一种二氢吡啶钙拮抗剂，对心脏和外周循环有选择性作用。Isradipine 是一种潜在可行的帕金森病神经保护剂。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Autophagy
作用靶点：Calcium Channel | Autophagy
In Vitro: Isradipine has much higher (＞40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels.
In Vivo: Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner.
Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine.
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