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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
3094-09-5
- 规格：
10 mM * 1 mL/500 mg/1 g/5 g/10 g/25 g/100 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥110.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥100.0 |
| 规格： | 1 g | 产品价格： | ￥130.0 |
| 规格： | 5 g | 产品价格： | ￥210.0 |
| 规格： | 10 g | 产品价格： | ￥336.0 |
| 规格： | 25 g | 产品价格： | ￥806.0 |
| 规格： | 100 g | 产品价格： | ￥3120.0 |
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Doxifluridine
CAS No. : 3094-09-5
MCE 国际站：Doxifluridine
产品活性：Doxifluridine 具有抗癌活性。Doxifluidine 是一种 5-FU 前药。Doxifluridine 是胸腺嘧啶酸合酶抑制剂。Doxifluridine 能通过协同多种药物增强对肿瘤的抑制。
研究领域：Apoptosis
作用靶点：Thymidylate Synthase
In Vitro: Doxifluridine (1-10 μM) inhibits angiogenesis by significantly inhibiting the expression of VEGF in FU-MMT-1 cells.
Doxifluridine (1-100 μM) slightly increases the expression of TSP-1 at low dose (1 μM) and inhibits the expression of TSP-1 at high dose (100 μM) in FU-MMT-1 cells.
Doxifluridine (100 μM) inhibits cell proliferation in HUVEC cells.
In Vivo: Doxifluridine (61.55 mg/kg; Intragastric administration; Single dose) has anticancer activity in BALB ⁄ cA Jcl-nu mice, and can significantly enhance anticancer activity in combination with TNP-470 (HY-101932).
Doxifluridine (200 mg/kg; Intraperitoneal injection; Single dose) can inhibit thymidine synthase activity in DMH-induced colon cancer mice.
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