- ￥1900
- MedChemExpress(MCE)
- 美国
- HY-12772
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
Itraconazole metabolite Hydroxy Itraconazole; R-63373
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
112559-91-8
- 规格：
1 mg
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Hydroxy Itraconazole
CAS No. : 112559-91-8
MCE 国际站：Hydroxy Itraconazole
产品活性：Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代谢物，Itraconazole 是一种三唑类抗真菌剂。
研究领域：Anti-infection | Metabolic Enzyme/Protease
作用靶点：Fungal | Drug Metabolite
In Vitro: Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.
In Vivo: The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.
相关产品：Bioactive Compound Library Plus | Ferrostatin-1 | Rapamycin | Cycloheximide | Staurosporine | Resveratrol | Hygromycin B | Tunicamycin | Clozapine N-oxide | Oligomycin | Camptothecin | Filipin complex | Amphotericin B | Calcimycin | Oseltamivir acid | Urolithin A | Nystatin | Ketoconazole | Itraconazole | Tofacitinib citrate | Valinomycin | Fluconazole | Mycophenolic acid | Phosphoramide mustard cyclohexanamine | Caspofungin diacetate | Toyocamycin | Leptomycin B | Idarubicin hydrochloride | Teriflunomide
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Electrochemical Detection of 8-Hydroxy-2-Deoxyguanosine Levels in Cellular DNA
(5 ), inflammatory disease (1 ) and carcinogenesis (1 –3 ,6 ). The 8-hydroxy-2-deoxyguanosine lesion (8-OHdG) is often used in the assessment of oxidative DNA damage and has become the de facto marker for oxidative damage to DNA. 8-OHdG
4-Hydroxy-2-Nonenal (4-HNE) Staining by Anti-HNE Antibody
In almost all aerobic cells, the oxygen metabolism generates reactive oxygen species (ROS), such as superoxide, hydroxyl radicals, and hydrogen peroxide. These ROS can peroxidize membrane lipids of a cell and its organelles
Site-directed hydroxy radical mapping of nucleosome positions in vitro
Introduction The dynamics of chromatin structure is becoming an area of increasing interest. Both thermal energy and ATP-dependent chromatin remodelling enzymes can alter nucleosome structure and positioning. In addition, modifications
技术资料暂无技术资料 索取技术资料
