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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Colosolic acid
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
4547-24-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥364.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥350.0 |
| 规格： | 10 mg | 产品价格： | ￥520.0 |
| 规格： | 25 mg | 产品价格： | ￥840.0 |
| 规格： | 50 mg | 产品价格： | ￥1260.0 |
| 规格： | 100 mg | 产品价格： | ￥1900.0 |
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Corosolic acid
CAS No. : 4547-24-4
MCE 国际站：Corosolic acid
产品活性：Corosolic acid (Colosolic acid) 是一种天然化合物，据报道具有抗肿瘤活性。Corosolic acid 可诱导癌细胞凋亡 (Apoptosis)。
研究领域：Autophagy | Apoptosis | JAK/STAT Signaling | Protein Tyrosine Kinase/RTK
作用靶点：Autophagy | Apoptosis | EGFR
In Vitro: Corosolic acid shows cytotoxicity for Hep G2, A549, SNU-C4, HeLa, K-562 cells, with ED50s of 0.4-5.0 μg/mL.
Corosolic acid (0-50 μg/mL) inhibits PKC activity in a dose-dependent way.
Corosolic acid (0-50 μM, 6-24 h) induces apoptosis and increases cells in the sub-G1 population in CT-26 cells.
Corosolic acid (20 μM, 0-24 h) inhibits HER2/HER3 heterodimerization and phosphorylation of HER2 and HER3 in HCT116 and SW480 cells.
In Vivo: Corosolic acid (5, 25 mg/kg/day, peritumor injection, 12 days) inhibits tumor growth and shows anti-angiogenic effect in CT-26 allograft colon carcinoma mice model.
Corosolic acid (10 and 20 mg/kg, i.p., every 2 days) inhibits tumor growth in a murine PC-3 xenograft model by activating ER stress.
Corosolic acid (10 mg/kg/d, supplemented in diet, 8 weeks) inhibits adipose tissue inflammation, and improves insulin resistance via AMPK activation in high-fat fed mice.
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文献和实验Overview of Receptor Allosterism
‐4547. Avlani, V., May, L.T., Sexton, P.M., and Christopoulos, A. 2004. Application of a kinetic model to the apparently complex behavior of negative and positive allosteric
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