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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
894-71-3
- 规格：
10 mM * 1 mL/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥500.0 |
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Nortriptyline hydrochloride
CAS No. : 894-71-3
MCE 国际站：Nortriptyline hydrochloride
产品活性：ortriptyline (Desmethylamitriptyline) hydrochloride 是 mitriptyline 的主要活性代谢物，是一种三环类抗抑郁剂。Nortriptyline hydrochloride 是一种有效的自噬 (autophagy) 抑制剂，并具有抗癌作用。
研究领域：Autophagy | Metabolic Enzyme/Protease | Apoptosis
作用靶点：Autophagy | Drug Metabolite | Apoptosis
In Vitro: Amitriptyline is metabolized by CYP2C19 to the active metabolite, Nortriptyline. Nortriptyline blocks the reuptake of Norepinephrine more potently than Serotonin.
Nortriptyline (6.25-100 μM; 24-72 h) hydrochloride markedly reducs the viability of TCCSUP and mouse MBT-2 bladder cancer cells in a concentration- and time-dependent manner.
Nortriptyline (12.55-100 μM; 24 h) hydrochloride induces cell cycle arrest and apoptosis in TCCSUP and MBT-2 cells.
Nortriptyline (12.55-100 μM; 24 h) hydrochloride induces both intrinsic and extrinsic apoptosis in these bladder cancer cells.
In Vivo: Nortriptyline (10-20 mg/kg; ip; every day; for three weeks) hydrochloride inhibits the growth of bladder tumors in mice inoculated with MBT-2 cells.
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