Deferoxamine甲磺酸去铁胺,138-14-7

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Deferoxamine mesylate

CAS No. : 138-14-7

MCE 国际站：Deferoxamine mesylate

产品活性：Deferoxamine mesylate (Deferoxamine B mesylate) 是一种铁螯合剂 (结合 Fe(III) 和许多其他金属阳离子)，被广泛用于减少铁在组织中的积累和沉积。Deferoxamine mesylate 可上调 HIF-1α 水平，具有较好的抗氧化活性，还能抗增殖和诱导癌细胞凋亡。Deferoxamine mesylate 可用于糖尿病、神经退行性疾病以及抗癌和抗 COVID-19 的研究。

研究领域：Autophagy  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB  |  Apoptosis  |  PI3K/Akt/mTOR

作用靶点：Autophagy  |  HIF/HIF Prolyl-Hydroxylase  |  Reactive Oxygen Species  |  Apoptosis  |  Akt

In Vitro: Deferoxamine mesylate (1 mM; 16 h or 4 weeks) improves HIF-1α function under hypoxic and hyperglycemic conditions and decreases ROS in MEFs cells.
Deferoxamine mesylate (100 μM; 24 h) increases InsR expression and activity and also induces an increase in p-Akt/total Akt/PKB levels.
Deferoxamine mesylate (5, 10, 25, 50, 100 μM; 7 or 9 days) inhibits the proliferation of tumor-associated MSCs and bone marrow MSCs.
Deferoxamine mesylate (5, 10, 25, 50, 100 μM; 7 days) induces apoptosis of MSCs.
Deferoxamine mesylate (10 μM ; 3 days) influencs the expression of adhesion proteins on MSCs.
Deferoxamine mesylate (100 μM; 24 h) induces autophagy mediated by the level of HIF-1α in SH-SY5Y cells.

In Vivo: Deferoxamine mesylate (6.57 μg/per; drip-on; once daily for 21 days) enhances wound healing and increases neovascularization in aged or diabetic mice.
Deferoxamine mesylate (200 mg/kg; i.p.; daily for 2 weeks) results in HIF-1α stabilization and increases glucose uptake, hepatic InsR expression, and signaling in vivo.

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