Hexylresorcinol4-己基间苯二酚,136-77

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Hexylresorcinol

CAS No. : 136-77-6

MCE 国际站：Hexylresorcinol

产品活性：Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然化合物，具有抗菌、驱虫、防腐和抗肿瘤活性。Hexylresorcinol 可诱导鳞癌细胞凋亡 (apoptosis)。Hexylresorcinol 是一种可逆、非竞争性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。Hexylresorcinol 具有抗 DNA 氧化损伤的保护作用。

研究领域：Anti-infection  |  Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Parasite  |  Bacterial  |  Apoptosis  |  Glucosidase  |  Endogenous Metabolite

In Vitro: Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it.
Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST).
Hexylresorcinol (1-10 µg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation.
Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis.
Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing.

In Vivo: Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol.

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