- ￥687 - 4750
- MedChemExpress(MCE)
- 美国
- HY-18728
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
724741-75-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1210.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥687.0 |
| 规格： | 10 mg | 产品价格： | ￥1100.0 |
| 规格： | 25 mg | 产品价格： | ￥2100.0 |
| 规格： | 50 mg | 产品价格： | ￥3250.0 |
| 规格： | 100 mg | 产品价格： | ￥4750.0 |
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STF-31
CAS No. : 724741-75-7
MCE 国际站：STF-31
产品活性：STF-31 是一种葡萄糖转运蛋白 1 (GLUT1) 的选择性抑制剂，IC50 值为 1 μM。STF-31 也是一种 NAMPT 抑制剂。STF-31 抑制肾细胞癌 (RCC) 4 细胞中的葡萄糖摄取。
研究领域：Membrane Transporter/Ion Channel | Autophagy
In Vitro: STF-31 (0.01-10 μM; 10 days) is specifically toxic to RCC4 cells, whereas RCC4/VHL cells are relatively unaffected. RCC4/VHL cells treated with STF-31 (5 μM; 10 days) largely recovery, whereas RCC4 cells under the same conditions does not.
?STF-31 (1.25-5 μM; 3 days) does not induce autophagy, apoptosis, or DNA damage. STF-31 causes a necrotic cell death.
?STF-31 reduces the efferocytosis of wild type and SLC2A1-overexpressing LR73 cells.
In Vivo: STF-31 (10 mg/kg; i.p.; twice daily for 2 days, followed by once daily for another 3 days) does not affect normal mice body weight, behavior, and ERG responses. STF-31 reduces light-induced CX3CR1gfp/+ mice microglial activation and retinal degeneration.
?STF-31 (10 mg/kg; i.p.) promotes accumulation of necrotic thymocytes after Dexamethasone-induced apoptosis in vivo.
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