NEP/MME/Neprilysin Antibody
Cat#:PL0304256
Isotype:Rabbit Polyclonal IgG
Immunogen:Peptide derived from human NEP/MME.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.
Alternate Names:
Neprilysin; Membrane metallo-endopeptidase; MME; CALLA; Neutral endopeptidase 24.11; Neutral endopeptidase; Enkephalinase; Atriopeptidase; Common acute lymphocytic leukemia antigen; DKFZp686O16152; MGC126681; MGC126707; CD10; NEP_HUMAN; NEP; Skin fibroblast elastase; SFE; CD 10.
Specificity Reaction:Hu, Mo, Rat, Dog, Pig, Cow, Hor,
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 FC: 1:100-500 IF: 1:100-500
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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