Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
n yeasts, Cdc6(Saccharomyces cerevisiae) and Cdc18(Schizosaccharomyces pombe) associate with the origin recognition complex(ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al.(1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene.
Alternate Names:
CDC18L;HsCdc18;p62(cdc6);CELL DIVISION CYCLE 18, S. POMBE, HOMOLOG-LIKE;CDC6(cell division cycle 6, S. cerevisiae) homolog;CELL CYCLE CONTROLLER CDC6;CDC6-related protein;Cdc18-related protein.
Specificity Reaction:Hu
Application Notes:WB: 1:100-200
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.