Mitofusin 1 Antibody

Mitofusin 1 Antibody

Cat#：PL0403275

Isotype:Rabbit Polyclonal IgG

Immunogen：peptide corresponding to a sequence at the N-terminal of human Mitofusin 1.

Purification: Immunogen affinity purified

Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

Background：

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is an 80­90 kDa mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN­2, and to undergo ubiquitination by MARCH5. MFN­1 has two key domains. One is a coiled­coil region that mediates MFN­1: MFN­1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion.

Specificity Reaction：Hu，Mo，Rat

Application Notes:WB: 1:100-500

Storage ：

Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

This product for research use only, not for use in humans, therapeutic or diagnostic procedures.

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