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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 保质期:
12个月
- 英文名:
Recombinant Cutaneous T-Cell Attracting Chemokine (CTACK)
- 库存:
1000
- 供应商:
上海信裕
| Organism species | Homo sapiens (Human) |
| Product No. | xy651Hu01 |
| Source | Prokaryotic expression |
| Host | E.coli |
| Purity | > 95% |
| UOM | 50ug |
| Predicted Molecular Mass | 15.8kDa |
| Concentration | n/a |
| Applications | SDS-PAGE; WB; ELISA; IP. |
| Endotoxin Level | <1.0EU per 1µg (determined by the LAL method) |
| Formulation | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
MHHHHHHSSGLVPRGSGMKETAAAKFERQHMDSPDLGTDDDDKAMADIGSEF-FLLPPS TACCTQLYRK PKLLRKV IQVELQEADG DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL PKLNFGMLRK MG
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
皮肤T-细胞虏获趋化因子(CTACK)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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文献和实验ITGA4(CD49D)信号通路、病理作用与靶向治疗药物研究梳理
等接头蛋白结合位点,其磷酸化修饰(如Ser1027)可调控信号转导。ITGA4主要与β1或β7亚基形成异二聚体(分别为VLA-4和α4β7),通过特异性识别配体中的Q-I-D-S或L-D-T序列,介导细胞与基质或内皮的黏附。 ITGA4的信号通路和调控 ITGA4本身虽不具备酶活性,但通过与β1或β7亚基形成异二聚体,构建了连接细胞外环境与细胞内骨架的独特双向信号转导机制。在“由内而外”的传导过程中,趋化因子或抗原刺激激活Rap1并招募Talin等接头蛋白,促使整合素胞外域从低亲和力弯曲构象
趋化因子介导的生物治疗 趋化因子是一类分子质量为8~11kDa的细胞因子样的分泌蛋白,可分为四类:即C-C,C-X-C,C-X3-C和XC趋化因子。其受体属于七次跨膜结构域G蛋白偶联受体。 将不同类型的趋化因子导人肿瘤细胞,能强化宿主抗肿瘤免疫反应。应用方法包括:将趋化因子基因导人肿瘤细胞,将重组蛋白注射人肿瘤,将趋化因子与肿瘤抗原结合的融合蛋白注入肿瘤,或者将趋化因子基因转导入DC或基质细胞。 使用单一趋化因子的疗法 将CCLl、CCL
CCR4:下一个明星免疫靶点?从基础机制到临床药物全景解读 1. CCR4靶点概述:生理功能与病理调控的核心作用 C-C 趋化因子受体 4(CCR4)是 G 蛋白偶联受体家族的重要成员,主要参与免疫细胞的募集、迁移及功能调控。作为 Th2 细胞和调节性 T 细胞(Regulatory T cells, Treg)的关键表面受体之一,CCR4 通过识别其配体 CCL17(TARC)和 CCL22(MDC),在免疫稳态维持、炎症反应及免疫耐受形成
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