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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 保质期:
12个月
- 英文名:
Recombinant Cluster Of Differentiation 40 Ligand (CD40L)
- 库存:
1000
- 供应商:
上海信裕
| Organism species | Rhesus monkey (Simian) |
| Product No. | xy119Si01 |
| Source | Prokaryotic expression |
| Host | E.coli |
| Purity | > 95% |
| UOM | 50ug |
| Predicted Molecular Mass | 14.4kDa |
| Concentration | 6.5 |
| Applications | SDS-PAGE; WB; ELISA; IP. |
| Endotoxin Level | <1.0EU per 1µg (determined by the LAL method) |
| Formulation | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
MHHHHHHSSGLVPRGSGMKETAAAKFERQHMDSPDLGTDDDDKAMADIGSEF-N REASSQAPFI ASLCLKSPGR FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN VTDPSQVSHG TGFTSFGLLK L
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
CD40配体(CD40L)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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文献和实验白细胞分化抗原及其功能 CD40L 即CDl54分子,属于TNFSF成员,为Ⅱ型膜蛋白。 人CD40L主要表达在活化的CD4+T细胞以及部分CD8+T细胞和YaT细胞。此外,CD40L还表达于活化的嗜碱粒细胞、肥大细胞、NK细胞、某些单核细胞以及活化B细胞。静止淋巴细胞不表达CD40L。CD40L往往以三聚体形式结合三聚体的CD40分子(TNFR超家族成员)发挥生物学作用,即传递B细胞活化的第二信号(见第九章)。缺少第二
CD40 分子 CD40 常用单克隆抗体或代号: G28- 5,EA- 5 主要表达细胞: B,M,FDC,并指细胞,上皮 [B] 分子质量(kDa)和结构: gp50(TNFR- SF) 功 能: B细胞生长、分化和记忆细胞产生,配体为CD40L,T- B相互作用 CD40 Plays a central role in regulating cell-mediated
CD40 / CD22 白细胞分化抗原及其功能 CD40 属于TNFR-SF,胞膜外区有4个富含牛胱氨酸重复序列(图6―2),表达于APC细胞,以及某些上皮细胞、内皮细胞、成纤维细胞、淋巴样并指细胞、FDC以及活化的单核细胞。浆细胞不表达CD40分子。 CD40结合CD40L(CDl54),胞质区Thr234是CD40介导信号转导关键的氨基酸残基。CD40-CD40L相互作用是B细胞活化中第二信号的主要来源,而且对于T
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