J2单克隆抗体,IgG2a亚型,是抗dsRNA的单克隆抗体,它已经成为检测dsRNA的黄金标准。J2抗体最初用于检测植物病毒,后来,2006年Weber et al这篇论文中表明,J2抗体可以检测到感染细胞内所有正链RNA病毒产生的大量双链RNA(dsRNA)。因此J2抗体被广泛应用于这一检测领域,发表文章达200多篇。
Antibody J2 reveals the colocalisation of dsRNA (labelled in green) and Hepatitis C virus core protein (labelled in red), indicating the location of putative virus assembly sites (arrows).
产品信息
货号
产品名称
规格
J2-1406
J2 anti-dsRNA IgG2a monoclonal antibody
200ug/500ug
参考文献 Schönborn, J., Oberstrass, J., Breyel, E., Tittgen, J., Schumacher, J. and Lukacs, N. (1991) Monoclonal antibodies to double-stranded RNA as probes of RNA structure in crude nucleic acid extracts. Nucleic Acids Res.19, 2993-3000.
Lukacs, N. (1994) Detection of virus infection in plants and differentiation between coexisting viruses by monoclonal antibodies to double-stranded RNA. J. Virol. Methods 47, 255-272.
Lukacs, N. (1997) Detection of sense:antisense duplexes by structure-specific anti-RNA antibodies. In: Antisense Technology. A Practical Approach, C. Lichtenstein amd W. Nellen (eds), pp. 281-295. IRL Press, Oxford.