NDRG3 Antibody

NDRG3 Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2025年11月26日
  • W, IP
  • Rabbit
  • H,M,R,Mk
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    • 详细信息
    • 询价记录
    • 技术资料
    • 抗体英文名

      NDRG3 Antibody

    • 抗原

      synthetic peptide corresponding to residues near the carboxy terminus of human NDRG3 protein

    • 应用范围

      W, IP

    • 宿主

      Rabbit

    • 供应商

      CST

    • 级别

      详见MSDS文件

    • 保质期

      详见说明书

    • 库存

      大量

    • 适应物种

      H,M,R,Mk

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W IP H M R Mk Endogenous 45 Rabbit
    Protocols
    Specificity / Sensitivity

    NDRG3 Antibody recognizes endogenous levels of total NDRG3 protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NDRG3 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from various cell lines and tissues using NDRG3 Antibody.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a mouse NDRG3 construct (+), using NDRG3 Antibody.

    Background

    The NDRG (N-Myc downstream-regulated gene) family, consisting of NDRG1, NDRG2, NDRG3, and NDRG4, are a group of structurally related proteins with roles in cell proliferation, differentiation, apoptosis, stress responses, and cell migration/metastasis (1-3). NDRG1 was originally identified as a protein that was up-regulated in N-Myc knockout mice (1). Proteins in the NDRG family, particularly NDRG1 and NDRG2, have been reported to be down-regulated in various cancer tissues, and have been suggested to function as a tumor suppressors (4,5).

    Members of the NDRG family each have distinct expression patterns; NDRG3 is most highly expressed in the testis, prostate, ovary, and brain (2,6,7). NDRG3 has also been shown to be up-regulated by androgen in prostate cell lines and can promote cell growth in those cells (8).

    1. Shimono, A. et al. (1999) Mech Dev 83, 39-52.
    2. Qu, X. et al. (2002) Mol Cell Biochem 229, 35-44.
    3. Zhou, R.H. et al. (2001) Genomics 73, 86-97.
    4. Yao, L. et al. (2008) Acta Biochim Biophys Sin (Shanghai) 40, 625-35.
    5. Ellen, T.P. et al. (2008) Carcinogenesis 29, 2-8.
    6. Okuda, T. and Kondoh, H. (1999) Biochem Biophys Res Commun 266, 208-15.
    7. Zhao, W. et al. (2001) Biochim Biophys Acta 1519, 134-8.
    8. Wang, W. et al. (2009) Int J Cancer 124, 521-30.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.


    For Research Use Only. Not For Use In Diagnostic Procedures.

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