- 询价
- Cell Signaling Technology
- 3283
- USA
- 2025年07月13日
- W
- Rabbit
- H,M,R,Hm,Pg
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- 详细信息
- 技术资料
- 抗体英文名：
Phospho-FAK (Tyr397) Antibody
- 抗原：
synthetic phosphopeptide corresponding to residues surrounding Tyr397 of human FAK
- 应用范围：
W
- 宿主：
Rabbit
- 适应物种：
H,M,R,Hm,Pg
- 供应商：
CST
- 库存：
大量
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Hm=Hamster Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R Hm Pg | Endogenous | 125 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Phospho-FAK (Tyr397) Antibody detects endogenous levels of FAK only when phosphorylated at Tyr397. This antibody may cross-react with overexpressed tyrosine phosphorylated EGF receptors. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr397 of human FAK. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from NIH/3T3 cells, untransfected or transfected with activated Src, using Phospho-FAK (Tyr397) Antibody (upper) or FAK Antibody #3285 (lower). |
| Background | Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival (1). Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ (2-5). Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK (6,7).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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