- 询价
- Cell Signaling Technology
- 3811
- USA
- 2025年10月04日
- W, IP
- Rabbit
- H,M,R
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
PI3 Kinase Class III Antibody
- 抗原：
synthetic peptide corresponding to human PI3K class III
- 应用范围：
W, IP
- 宿主：
Rabbit
- 适应物种：
H,M,R
- 库存：
大量
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R | Endogenous | 100 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | PI3 Kinase Class III Antibody detects endogenous levels of total PI3K class III protein. This antibody may cross-react with an unidentified protein at ~55 kDa. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human PI3K class III. Antibodies are purified peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from C6 and RN33B cells using PI3 Kinase Class III Antibody. |
| Background | Three distinct types of phosphoinositide 3-kinases (PI3K) have been characterized. Unlike other PI3Ks, PI3K class III catalyzes the phosphorylation of phosphatidylinositol at the D3 position, producing phosphatidylinositol-3-phosphate (PIP3) (1). PI3K class III is the mammalian homolog of Vps34, first identified in yeast. PI3K class III interacts with the regular subunit p150, the mammalian homolog of Vps15, which regulates cellular membrane association through myristoylation (2,3). PIP3 recruits several proteins with FYVE or PX domains to membranes regulating vesicular transport and protein sorting (4). Moreover, PI3K class III has been shown to regulate autophagy, trimeric G-protein signaling, and the mTOR nutrient-sensing pathway (5). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Measuring PI3K Lipid Kinase Activity
Class IA phosphoinositide-3 kinases (PI3Ks) signaling has recently emerged as a key element in cancer development because of its ability to trigger a complex panoply of cellular responses controlling survival and proliferation. Many cancers
Measurement of Phosphoinositide 3-Kinase Activity
adaptor molecule ( 1 ). The class II PI 3-kinases are characterized by the presence of a C-2 domain at the carboxy terminus and utilize predominantly PtdIns and PtdIns(4)P as substrates (e.g., PI3K-C2α), whereas the class III PI 3-kinases utilize
Measuring Insulin-Stimulated Phosphatidyl-Inositol 3-Kinase Activity
Numerous growth factors, hormones, and transforming oncogenes activate phosphatidylinositol 3-kinase (PI3K), an enzyme that phosphorylates the 3′-hydroxyl position of phosphoinositides to generate the intracellular messengers
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