- 询价
- Cell Signaling Technology
- 4448
- USA
- 2025年10月03日
- W, IP
- H,Mk
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- 详细信息
- 技术资料
- 抗体英文名：
AFP (D12C1) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues near the carboxy terminus of human AFP protein
- 应用范围：
W, IP
- 级别：
详见MSDS文件
- 库存：
大量
- 适应物种：
H,Mk
- 保质期：
详见说明书
- 供应商：
CST
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H (Mk) | Endogenous | 65 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | AFP (D12C1) Rabbit mAb recognizes endogenous levels of total AFP protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human AFP protein. Western Blotting
Western blot analysis of extracts from Hep G2 cells using AFP (D12C1) Rabbit mAb. |
| Background | Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the serum of the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells (1,2). The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Elevated serum levels are predictive of hepatocellular carcinoma (3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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