- 询价
- R&D
- 美国/中国
- xy-39240
- 2025年07月12日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 询价记录
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Biotin Labeled (SIGNET)保存于运输说明：
- Store at -20°C or below.
- 详细信息：
-
Description Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Beta Amyloid (Aβ) Monoclonal Antibody, 4G8, Biotinylated
(Formerly Signet Catalog Nos.: 9240-02, 9240-05, 9240-10)
Covance is the Exclusive Provider of this Antibody ProductIntended Use 
**Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 4G8 Form Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Biotin Labeled (SIGNET)Biotin Labeled Antibody (in PBS; no preservatives or carrier proteins) Host Mouse Species Reactivity Human, Mouse IsoType IgG2b [Ab] Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> 1 mg/mL Specificity Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> This antibody is reactive to amino acid residues 17-24 of beta amyloid. The epitope lies within amino acids 18-22 of beta amyloid (VFFAE). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Signet’s biotinylated beta amyloid antibody 4G8 reacts to the abnormally processed isoforms, as well as precursor forms. Uses Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> This antibody is effective in immunoblotting, immunohistochemistry (IHC), immunoprecipitation (IP), and ELISA. Suggested Working Dilution Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> The optimal working dilution should be determined for each specific assay condition. - IHC:
Tissue Sections: Formalin-fixed human paraffin-embedded sections
Pretreatment: Formic acid (70%) for 10-30 minutes at room temperature
Storage Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Biotin Labeled (SIGNET)Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009.
Kimura N, et al. Age-related changes of intracellular Abeta in cynomolgus monkey brains. Neuropath Appl Neurobiol 31(2):170-80, 2005.
Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.
Iijima K, et al. Dissecting pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer’s disease. PNAS 101(17):6623-6628, 2004.
Li M, et al. Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microgliamediated neurotoxicity. J Neurochem 91:623-33, 2004.
Poduloso JF, et al. Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer’s disease amyloid plaques. Biochem 43:6064-6075, 2004.
Venezia V, et al. Apoptotic cell death influences the signaling activity of the amyloid precursor protein through SchA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells. J Neurochem 90:1359-1370, 2004.
Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Comm 2:121-130, 1988.
Kim KS, et al. Neurosci Res Comm 7:113, 1988.Warranty/Conditions Exclusively Provided by Covance - Alpha Secretase Cleavage" height="1" src="https://store.crpinc.com/images/spacer.gif" style="list-style: none; padding: 0px; margin: 0px; border: 0px;" width="5"> Covance products may not be resold or modified for resale without prior written approval. - IHC:
- Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Biotin Labeled (SIGNET)
- xy-2918R RAP1GAPRAP1GAP酶激活蛋白抗体
xy-6270R Ret原癌基因酪氨酸蛋白激酶受体RET/多发性内分泌腺瘤和甲状腺髓样癌蛋白抗体
xy-6271R phospho-Ret(Tyr1062)磷酸化原癌基因酪氨酸蛋白激酶受体RET抗体
xy-5830R RAB21G蛋白家族RAB21蛋白抗体
xy-2951R SQSTM1泛素结合蛋白P62抗体
xy-9872R Rap2ARap2A抗体
xy-4912R Reg3 gamma胰岛β细胞生长因子Reg IIIγ抗体
xy-4911R Reg3 beta胰岛β细胞生长因子Reg IIIα 抗体
xy-9655R RIMKLA核糖体蛋白S6修饰样蛋白A抗体
xy-8500R RFTN2RFTN2蛋白抗体
xy-9840R RNF213环指蛋白213
xy-7596R RIP3受体结合丝氨酸苏氨酸激酶3抗体
xy-7597R RIP5受体结合丝氨酸苏氨酸激酶5抗体
xy-12402R RBM15RNA结合蛋白15抗体
xy-6320R RNF47环指蛋白47抗体
xy-11125R ROM1视网膜感光细胞外节膜蛋白1抗体
xy-9299R RMND5BRMND5B蛋白抗体
xy-9253R RNF133环指蛋白133抗体
xy-7566R RHBDD3垂体瘤细胞凋亡抗体
xy-7568R RNF122环指蛋白122抗体
xy-7572R RRAGCRAS相关GTP结合蛋白C抗体
xy-7569R RNF36环指蛋白36抗体
xy-7567R RIP1受体相互作用蛋白激酶1抗体
xy-7570R RNF7环指蛋白7抗体
xy-7571R RPS3核糖体蛋白S3抗体
xy-7574R RRAS原癌基因R-Ras抗体
xy-3384R Phospho-Ret (Tyr905)磷酸化指状蛋白RET抗体
xy-7768R RCC2染色体浓缩调节蛋白2抗体
xy-7766R RACGAP1Rho GTP酶激活蛋白GAP抗体
xy-6442R Retinol binding protein视黄醇结合蛋白抗体
xy-9079R RGC32补体应答基因32抗体
xy-13616R RSBN1L精子细胞碱性蛋白1样蛋白抗体
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Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody, Biotin Labeled (SIGNET)
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