- 询价
- R&D
- 美国/中国
- xy-3730
- 2025年07月15日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)详细信息：
-
Description 
Purified Monoclonal Antibody against Lymphatic Endothelial Marker
(Formerly Signet Catalog Nos: 730-001, 730-01, 730-16 L1 Predilute, 730-26 L2 Predilute)Intended Use ** In Vitro Diagnostic (IVD) ** Clone D2-40 Form Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA) Host Mouse Species Reactivity Human IsoType D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)IgG1 Specificity Clone D2-40 reacts with a O-linked sialoglycoprotein (MW 40kDa) found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors. In recent studies clone D2-40 (D240) has shown staining in lymphatic channel endothelium but not in the adjacent capillary.
This antibody was developed using M2A.
Concentrated Format:
SIG-3730-100 [0.1 mL]
SIG-3730-1000 [1 mL]
Prediluted Formats:
SIG-3730-16 [6 mL]
SIG-3730-26 [6 mL]
Both are ready-to-use with either a Biotin-based (USA Ultra Streptavidin Detection, SIG-32250) or Biotin-free (ACUITYAdvanced Polymer Detection, SIG-32902) detection systems.Uses D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)This antibody is effective in immunoblotting and immunohistochemistry (IHC). Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 0.1 - 0.5 ug/mL
- IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues, frozen sections
Pretreatment: Not required
Incubation: 60 minutes at room temperature
Storage Store between 2-8°C. References Choi WW, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF family gene expression. Mod Pathol 18:143-52, 2005.
Chu, AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 18:105-110, 2005.
Dumoff KL, et al. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 18:97-104, 2005.
Galambos C, Nodit L. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Ped Dev Pathol 8(2):181-9, 2005.
Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 11:47-50, 2004.
Fogt F, et al. Observation of lymphatic vessels in orbital fat of patients with inflammatory conditions: A form fruste of lymphangiogenesis? Int J Molec Med 13:681-683, 2004.
Franchi A, et al. Tumor lymphangiogenesis in head and neck squamous cell carcinoma.Cancer 101(5):973-978, 2004.
Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 31:362-367, 2004.
Giorgadze TA, et al. Lymphatic vessel density is significantly increased in melanoma. J Cutan Pathol 31:672-677, 2004.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)
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). However, since 2000, humanized and human mAbs have been entering clinical study at approximately the same rate (4.3 versus 4.5 mAbs per year, respectively). Figure 1 | Categories of monoclonal antibody cancer therapeutics entering clinical study during 1980–1989
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antibodies immunoreactive with ??smooth muscle actin. Similarly, lymphatic endothelial cells can be detected by antibodies immunoreactive to the hyaluronan receptor LYVE?1. Together, these approaches allow functional and morphological analysis of blood
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D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)
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