- 询价
- R&D
- 美国/中国
- xy-3730
- 2025年07月15日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)详细信息：
-
Description 
Purified Monoclonal Antibody against Lymphatic Endothelial Marker
(Formerly Signet Catalog Nos: 730-001, 730-01, 730-16 L1 Predilute, 730-26 L2 Predilute)Intended Use ** In Vitro Diagnostic (IVD) ** Clone D2-40 Form Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA) Host Mouse Species Reactivity Human IsoType D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)IgG1 Specificity Clone D2-40 reacts with a O-linked sialoglycoprotein (MW 40kDa) found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors. In recent studies clone D2-40 (D240) has shown staining in lymphatic channel endothelium but not in the adjacent capillary.
This antibody was developed using M2A.
Concentrated Format:
SIG-3730-100 [0.1 mL]
SIG-3730-1000 [1 mL]
Prediluted Formats:
SIG-3730-16 [6 mL]
SIG-3730-26 [6 mL]
Both are ready-to-use with either a Biotin-based (USA Ultra Streptavidin Detection, SIG-32250) or Biotin-free (ACUITYAdvanced Polymer Detection, SIG-32902) detection systems.Uses D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)This antibody is effective in immunoblotting and immunohistochemistry (IHC). Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 0.1 - 0.5 ug/mL
- IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues, frozen sections
Pretreatment: Not required
Incubation: 60 minutes at room temperature
Storage Store between 2-8°C. References Choi WW, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF family gene expression. Mod Pathol 18:143-52, 2005.
Chu, AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 18:105-110, 2005.
Dumoff KL, et al. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 18:97-104, 2005.
Galambos C, Nodit L. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Ped Dev Pathol 8(2):181-9, 2005.
Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 11:47-50, 2004.
Fogt F, et al. Observation of lymphatic vessels in orbital fat of patients with inflammatory conditions: A form fruste of lymphangiogenesis? Int J Molec Med 13:681-683, 2004.
Franchi A, et al. Tumor lymphangiogenesis in head and neck squamous cell carcinoma.Cancer 101(5):973-978, 2004.
Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 31:362-367, 2004.
Giorgadze TA, et al. Lymphatic vessel density is significantly increased in melanoma. J Cutan Pathol 31:672-677, 2004.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)
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D2-40 Lymphatic Endothelial Marker Monoclonal Antibody, Purified (SIGNET)
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