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- biolegend
- 916603
- 2025年09月01日
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- 克隆性：
多克隆
- 抗体英文名：
Lymphatic endothelial marker D2-40
- 抗体名：
淋巴管内皮标记物D2-40抗体
- 规格：
6ml
D2-40 Lymphatic Endothelial Marker Monoclonal Antibody
Intended Use
In Vitro Diagnostic (IVD). Use in immunohistochemistry (IHC) test methods only.
The monoclonal antibody D2-40 is used for the in vitro examination of human biological samples using immunohistochemistry (IHC) methods for the qualitative identification of D2-40 Lymphatic Endothelial Marker. The clinical interpretation of any staining or its absence should be complemented by morphological studies and proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was developed using M2A.
Formulation
Phosphate-buffered solution with BSA + 0.1% NaN3.
Preparation
Ammonium sulfate precipitated TCS.
Storage & Handling
Store between 2°C and 8°C.
Application
IHC
Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining.
The optimal working dilution should be determined for each specific assay condition.
• IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (Cat. No. 929501).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues, frozen sections
Pretreatment: Not required
Incubation: 60 minutes at room temperature
Precautions for Use: Use appropriate personal protective equipment and safety practices per universal precautions when working with this reagent. Refer to the reagent safety data sheet.
Application Notes
This antibody is effective in immunohistochemistry (IHC).
Clone D2-40 reacts with a O-linked sialoglycoprotein (MW 40 kD) found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors. Clone D2-40 (D240) has shown staining in lymphatic channel endothelium but not in the adjacent capillary.
Concentrated Format:
Cat. No. 916601 (Formerly: SIG-3730-100) [0.1 ml]
Cat. No. 916602 (Formerly: SIG-3730-1000) [1 ml]
Prediluted Formats:
Cat. No. 916603 (Formerly: SIG-3730-16) [6 ml]
Cat. No. 916604 (Formerly: SIG-3730-26) [6 ml]
Both are ready-to-use with a Biotin-based (USA Ultra Streptavidin Detection, Cat. No. 929501) detection system.
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文献和实验YKL-40: A Novel Marker Shared by Chronic Inflammation and Oncogenic Transformation
YKL-40, a member of ‘mammalian chitinase-like proteins’, is secreted by macrophages, neutrophils, chondrocytes, endothelial-, vascular smooth muscle-, and cancer cells. High serum YKL-40 is a biomar-ker of poor prognosis in patients
Assessment of Endothelial Damage/Dysfunction: A Focus on Circulating Endothelial Cells
Endothelial injury represents a major initiating step in the pathogenesis of vascular disease and atherosclerosis. The identification and quantification of circulating endothelial cells (CECs) has evolved as a novel marker of endothelial
CD40 分子 CD40 常用单克隆抗体或代号： G28- 5,EA- 5 主要表达细胞： B,M,FDC,并指细胞,上皮 [B] 分子质量(kDa)和结构： gp50(TNFR- SF) 功 能： B细胞生长、分化和记忆细胞产生,配体为CD40L,T- B相互作用 CD40 Plays a central role in regulating cell-mediated
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