- 询价
- R&D
- 美国/中国
- xy-39180
- 2025年07月15日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Amyloid Precursor Protein (APP) Monoclonal Antibody, Purified (SIGNET)保存于运输说明：
- Store at -20°C or below
- 详细信息：
-
Description 
Monoclonal Antibody against Amyloid Precursor Protein (APP)
(Formerly Signet Catalog Nos.: 9180-02, 9180-05 and 9180-10)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone Amyloid Precursor Protein (APP) Monoclonal Antibody, Purified (SIGNET)1G6 Form Purified Antibody (in PBS; no preservatives or carrier proteins) Host Mouse IsoType IgG2b [Ab] 1 mg/mL Specificity Epitope lies within amino acids 573-596 of amyloid precursor protein. Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC) and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot
- IHC
Amyloid Precursor Protein (APP) Monoclonal Antibody, Purified (SIGNET)Tissue Sections: Formalin-fixed, paraffin-embedded tissues
Pretreatment: The epitope must be re-exposed in fixed tissue by pretreatment of tissue using formic acid (70%) for 10-30 minutes at room temperature - ELISA
Storage Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Amyloid Precursor Protein (APP) Monoclonal Antibody, Purified (SIGNET)
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文献和实验Interaction of the Presenilins with the Amyloid Precursor Protein (APP)
the deposition of amyloid Aβ peptide. The latter is released from its cognate amyloid precursor protein (APP) by a two-step proteolytic conversion: first, proteolysis of APP by β-secretase, which releases the N-terminus of Aβ, and second, conversion
Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins
including fly (4 ), nematode (5 ), and fish (6 ). In mammals, two APP-like genes, amyloid precursor-like protein 1 (APLP1) and 2 (APLP2), have been isolated (7 ,8 ). The amino acid sequences of these APP family proteins are highly conserved, especially
Using an Amyloid Precursor Protein (APP) Reporter to Characterize α-Secretase
Human genetic studies suggest decreasing amyloid peptide (Aβ) levels in the brain could alter the course of Alzheimer’s disease (AD) (1 -4 ). Proteolytic cleavages govern the level of Aβ generated from the amyloid precursor protein (APP). β
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