- 询价
- Abcam
- 中国/美国/德国
- xy11050-RP01
- 2025年07月15日
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- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
β-NGF / Beta-NGF抗体
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, CHO cell-derived, recombinant human Beta-NGF ( rh Beta-NGF ; Catalog#11050-HNAC ; NP_002497.2 ; Ser 122- Arg 239 ). Total IgG was purified by Protein A affinity chromatography.
β-NGF / Beta-NGF抗体背景综述
As the first one of a series of neurotrophic factors, nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF, was demonstrated to exhibits the growth stimulating activity of NGF. β-NGF is a target-derived secreted homodimeric protein of two 120-amino acid mature polypeptides after proteolytic removal of the signal and pro peptide. NGF acts via at least two receptors on the surface of cells, TrkA and p75 receptors to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In additon to its neurotropic activities, studies indicated that NGF may also have an important role in the regulation of the immune system. The synthesis of β-NGF in astrocytes is enhanced by various other cytokines including IL-1, TNF-α , PDGF and TGF-β .Defects in β-NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) characterized by degeneration of dorsal root and autonomic ganglion cells, as well as sensory and/or autonomic abnormalities.
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文献和实验人神经生长因子（NGF ） 酶联免疫分析 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本神经生长因子（NGF ） 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中人神经生长因子（ NGF ） 水平。用纯化的人神经生长因子（ NGF ） 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入神经生长因子（ NGF ） ，再与 HRP 标记的神经
Mutation Analysis in -Sarcoglycan (LGMD2F)
encoding dystrophin-associated glycoproteins (1 –3 , and references therein). Mutations in -sarcoglycan (SG) (4 ,5 ) β -SG (6 ,7 ) γ -SG (8 ),δ -SG (9 ) cause LGMD2D, LGMD2E, LGMD2C, and LGMD2F, respectively. In these forms, when any SG is missing
而蛇行，以氢键结合而成的链内β结构。将此结构称为交联β结构（ crossβ． form）。β结构在 X射线衍射图上，具有 3.3， 6.7的面间隔为其特征。另外β结构在 217mm有负的圆偏振光二色性吸收带，可与α螺旋相区别。
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