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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule Valproic Acid
- 库存：
1
- 供应商：
上海信裕
- Stemolecule Valproic Acid保存于运输说明：
- 4°C protected from light. Following reconstitution, store aliquots at -20°C
- 详细信息：
-
Stemolecule™ Valproic Acid
Stemolecule™ Valproic Acid is the highest purity preparation available, only from Stemgent. Valproic acid (VPA; sodium valproate) is a cell-permeable, short-chain fatty acid that inhibits histone deacetylase (HDAC; IC50 = 400 μM for HDAC1) and induces differentiation of certain cell lines. At concentrations ranging from 0.35 mM to 1.04 mM, VPA causes inositol depletion, inhibits GSK-3β and GSK-3β, activates the ERK pathway, produces neurotropic effects, and s timulates peroxisome proliferator-activated receptor (PPAR) activity. Dr. Douglas Meltons laboratory has reported that VPA improves the efficiency of reprogramming mouse embryonic fibroblasts (MEF) into induced pluripotent stem (iPS) cells compared to other DNA methyltransferase and HDAC inhibitors1. The efficiency of generating iPS cells when treated with VPA was 100 fold higher compared to MEFs transduced with four transcription factors (Oct4, Klf4, Sox2, and c-Myc) alone. Also, VPA enhanced iPS generation in a three-factor transduction (Oct4, Klf4 and Sox2) without introduction of the c-Myc oncogene that might be tumorigenic in cells derived from iPS cells1. View Poster
Stemolecule Valproic Acid产品参数
Chemical Formula C8H15NaO2 Structure Molecular Weight 166.2 CAS Number 1069-66-5 PubChem Substance ID 24277744 Purity >99% by dried basis assay Formulation White crystalline solid Solubility Stemolecule Valproic Acid Soluble in DMSO (100 mM) or water (30 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 3008 µl of DMSO to 5 mg of compound. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage 4°C protected from light. Following reconstitution, store aliquots at -20°C Stability Stock solutions stable at -20°C for 6 months Quality Control The purity of VPA was determined by dried basis assay per European guideline. The accurate mass and structure of VPA was determined by mass spectrometry and NMR, respectively. Cellular toxicity of VPA was tested by using HeLa and HEK293 cells. References - Huangfu, D. et al., Nat. Biotechnol., 2008, (published online June 22nd 2008).
- Stemolecule Valproic Acid
- xy-2446xy phospho-eIF4E(pSer209)(phospho-Eukaryotic translation initiation factor 4E)磷酸化eIF-4E（Ser209）抗原
xy-1398xy ELK1细胞转录因子ELK1抗原
xy-1756xy Elastin弹性蛋白抗原
xy-2651xy ELAVL1/HuR peptideELAVL1/HuR多肽抗原
xy-0558xy Emp1 (epithelial membrane protein 1)表皮膜蛋白1抗原
xy-1331xy sFRP-4(Secreted frizzled-related protein 4; Frizzled protein, human endometrium)抗子宫内膜抗原
xy-0547xy Endostatin内皮抑素/内皮他丁抗原
xy-0658xy E.coli O6 (Escherichia coli O6)E.coli O6大肠杆菌菌体蛋白
xy-2100xy EPEC/E.coli(enteropathogenic E．coli，EPEC)普通大肠埃希菌菌体蛋白（非致病性）
xy-1763xy EphA1 R(Ephrin A1 Receptor)EphA1-R受体抗原
xy-1424xy EPOR peptide红细胞生成素受体抗原
xy-1522xy phospho-ERK1/MAPK-1/2(pThr183 + pTyr185)磷酸化丝裂原活化蛋白激酶1/2抗原
xy-0996xy ERK(Extracellular signal-regulated kinase)丝裂原活化蛋白激酶抗原
xy-1020xy MAPK1/ERK3 (Mitogen-activated protein kinase 3; P44MAPK)丝裂原活化蛋白激酶3抗原
xy-1319xy MAPK4(Mitogen-activated protein kinase 4)丝裂原活化蛋白激酶4抗原
xy-0894xy ER- Alpha(phospho-Ser167)peptide人磷酸化雌激素受体α多肽抗原
xy-1643xy ER- Alpha(phospho-Tyr537)peptide磷酸化雌激素受体α抗原
xy-0253xy ER- Alpha /ER alpha peptide雌激素受体α抗原
xy-2098xy ER- Alpha/ER alpha peptide雌激素受体α抗原
xy-0255xy ER- Beta (Estrogen receptor-beta) peptide雌激素受体β抗原
xy-1285xy ets1/E26 (E-twenty six 1)Ets转录因子家族ets1抗原
xy-0983xy EV71(Human enterovirus 71)VP1(CT)肠道病毒71型/手足口病病毒抗原(C端)
xy-2221xy ATEXPA10 peptide植物扩张蛋白ATEXPA10（拟南芥）抗原
xy-1343xy Ezrin/Radixin埃兹蛋白（多肽）
xy-0949xy F1 operon positive regulatory protein(NT)鼠疫耶尔森氏菌F1荚膜蛋白(N端多肽）
xy-0950xy F1 operon positive regulatory protein(CT)鼠疫耶尔森氏菌F1荚膜蛋白(C端多肽）
xy-2135xy FABP(brain) (Fatty acid-binding protein brain)脑型脂肪酸结合蛋白抗原
xy-0511xy FADD (Fas-associated protein with death domain)Fas死亡结构域相关蛋白抗原
xy-1340xy FAK(Focaladhesin kinase)粘着斑激酶抗原
xy-1639xy phospho-FAK(pTyr577)磷酸化粘着斑激酶抗原
xy-1642xy phospho-FAK(pSer732)(phospho-Focal adhesion kinase)磷酸化粘着斑激酶抗原
xy-1765xy FAST kinase(Fas-activated serine/threonine kinase)Fas活化的丝/苏氨酸激酶抗原
xy-1157xy FBN1 (fibrillin 1)原纤维蛋白1抗原
xy-1256xy FGF4/HSTF1/HBGF-4(Fibroblast Growth Factor4)纤维母细胞生长因子4抗原
xy-1257xy FGF5 peptide纤维母细胞生长因子5抗原
xy-0809xy Fibulin 1衰老关键蛋白抗原
xy-1170xy FOS BFosB抗原
xy-1188xy FRA2/FOSL2(Fos related/like antigen 2)FOS样抗原2
xy-2585xy FOXF1(Forkhead box protein F1)叉头蛋白F1抗原
xy-1775xy FOXJ1/HFH-4 peptide插头蛋白J1抗原
xy-1275xy FoxP1(Forkhead box P1)FoxP1（T细胞转录因子）抗原
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文献和实验of pluripotent P19 cells into skeletal muscle lineage by using histone deacetylase inhibitor, valproic acid and the ligand of retinoic acid receptor, all-trans retinoic acid.
Examination of the Axial Skeleton of Fetal Rodents
mutation or as a result of xenobiotic exposure, may disrupt this patterning and lead to a variety of skeletal alterations. Chemical agents including valproic acid (1 ), retinoic acid (2 ), salicylate (3 ), and acetazolamide (4 ) have been shown to cause
Generation of iPS Cells from Human Skin Biopsy
human fibroblasts from skin biopsies using retroviral transduction of OCT4, SOX2, KLF4, and c-MYC with the addition of the histone deacetylase (HDAC) inhibitor, valproic acid (VPA). Characterized patient-specific iPS cell lines can be obtained
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