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- ATCC
- 美国/中国
- xy-7118
- 2025年07月13日
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- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Thio-ccPA
- 库存：
1
- 供应商：
上海信裕
- Thio-ccPA详细信息：
-
Description: Thio-ccPA is a stabilized analogue of carbacyclic phosphatidic acid (ccPA). It inhibits the lysoPLD activity of Autotaxin (ATX) and acts as an LPA1/3 receptor antagonist. Thio-ccPA decreases the viability of B16F10, A375, and MeWo melanoma cell lines. Addition of endogenous LPA did not reverse the effects of Thio-ccPA in B16F10 cells. Thio-ccPA decreased the number of pulmonary and non-pulmonary metastases in a B16F10 metastatic melanoma mouse model.
Thio-ccPAStorage
- -20 °C
References: 1) M.K. Altman, et al. “Targeting melanoma growth and viability reveals dualistic functionality of the phosphonotthionate analogue of carba cyclic phosphatidic acid” Molecular Cancer, 2010, 9, 140. 2) Y. Xu, et al. “Phosphonothioate and fluoromethylene phosphonateanalogues of cyclic phosphatidic acid: novel antagonists of lysophosphatidic acid receptors” J. Med. Chem., 2006, 49, 5309.
Thio-ccPA
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