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Mouse CNDP2

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  • ¥840 - 17600
  • SinoBio
  • 国产
  • CJ14
  • 2025年11月07日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      蛋白表达区间:Met1-Asn475

    • 保质期

      See instructions

    • 英文名

      标签:C-6His

    • 库存

      表达系统:Human Cells

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥840.0
    规格:50ug产品价格:¥2520.0
    规格:500ug产品价格:¥12320.0
    规格:1mg产品价格:¥17600.0
    产品描述
    Recombinant Mouse Cytosolic Non-specific Dipeptidase is produced by our Mammalian expression system and the target gene encoding Met1-Asn475 is expressed with a 6His tag at the C-terminus.
    蛋白编号
    Q9D1A2
    产品别称
    CNDP2;CNDP dipeptidase 2;Cytosolic non-specific dipeptidase;Glutamate carboxypeptidase-like protein 1;Cn2
    偶联
    Unconjugated
    分子量
    53.8 KDa
    表观分子量
    56-60 KDa, reducing conditions
    剂型描述
    Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    运输条件
    • The product is shipped on dry ice/polar packs.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Store at ≤-70°C, stable for 6 months after receipt.
    • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
    • Please minimize freeze-thaw cycles.
    产品背景
    Mouse cytosolic non-specific dipeptidase(CNDP2) is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 has 2 Isoform: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 hydrolyzes a variety of dipeptides including L-carnosine and has a strong preference for Cys-Gly. It is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis. It may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.

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    图标文献和实验
    该产品被引用文献

    Mouse cytosolic non-specific dipeptidase(CNDP2) is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 has 2 Isoform: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 hydrolyzes a variety of dipeptides including L-carnosine and has a strong preference for Cys-Gly. It is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis. It may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.

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      。先前研究证明,细胞溶质酶 CNDP2 可通过乳酸和苯丙氨酸的缩合来催化 Lac-Phe 的合成,然而该生化反应的生理相关性尚不清楚。 CNDP2 在巨噬细胞、单核细胞和一些免疫细胞及上皮细胞中广泛表达,这些细胞和其他 CNDP2+细胞类型均可分泌 Lac-Phe。这提示除了肌肉以外还有许多其他细胞类型可以感知并对身体运动做出反应。 图 3:来源 Nature Lac-Phe 抑制食物摄入量和肥胖,改善葡萄糖稳态 当发现血浆代谢物 Lac-Phe 的重要作用后,本研究开始持续对高脂

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    文献支持
    Mouse CNDP2
    ¥840 - 17600