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Human Serpin A5

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  • ¥1200 - 17600
  • SinoBio
  • 国产
  • C535
  • 2025年12月26日
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    • 文献和实验
    • 技术资料
    • 保存条件

      蛋白表达区间:His20-Pro406

    • 保质期

      See instructions

    • 英文名

      标签:C-6His

    • 库存

      表达系统:Human Cells

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥1200.0
    规格:50ug产品价格:¥3520.0
    规格:500ug产品价格:¥12320.0
    规格:1mg产品价格:¥17600.0
    产品描述
    Recombinant Human Serine Protease Inhibitor-clade A5 is produced by our Mammalian expression system and the target gene encoding His20-Pro406 is expressed with a 6His tag at the C-terminus.
    蛋白编号
    AAH08915.1
    产品别称
    Plasma Serine Protease Inhibitor; Acrosomal Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; PAI-3; PAI3; Protein C Inhibitor; PCI; Serpin A5; SERPINA5; PCI; PLANH3; PROCI
    偶联
    Unconjugated
    分子量
    44.7 KDa
    表观分子量
    50-60 KDa, reducing conditions
    剂型描述
    Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    复溶
    • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
    • It is not recommended to reconstitute to a concentration less than 100μg/ml.
    • Dissolve the lyophilized protein in distilled water.
    • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
    运输条件
    • The product is shipped at ambient temperature.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
    • Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
    • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    产品背景
    Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.

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    图标文献和实验
    该产品被引用文献

    Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.

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    • Thin-Layer Chromatographic Analysis of Human CYP3A-Catalyzed Testosterone 6-Hydroxylation

      At least two cytochromes P450 belonging to the CYP3A subfamily may be expressed in adult human liver (1 ), CYP3A4 and CYP3A5. A third enzyme, CYP3A7, is expressed in human fetal liver (2 ). The CYP3A enzymes account for an estimated ~30

    • Nature 报道史上最强「致矮基因」,这个基因突变让人变矮 4 厘米!

      而出。研究人员因此猜测 rs200342067 基因频率的升高是自然对 rs12441775 正向选择的结果,但进一步研究发现两者并没有明显的相关性。两者选择的驱动因素是否一致依旧未知。   由于 FBN1 处在 SLC24A5 的下游,而 SLC24A5 是负责皮肤色素沉着的关键基因,也是一个广为人知的正向选择的例子。所以研究人员猜测 FBN1 的 rs200342067 等位基因频率的上升可能是 SLC24A5 等位基因正向选择的长距离调节作用的结果。但通过与 SLC24A5 等位基因 rs

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    文献支持
    Human Serpin A5
    ¥1200 - 17600