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- 2025年11月04日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Ile21-Met119
- 保质期：
See instructions
- 英文名：
标签:C-Fc
- 库存：
表达系统:Human Cells
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥370.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥1100.0 |
| 规格： | 500ug | 产品价格： | ￥8700.0 |
| 规格： | 1mg | 产品价格： | ￥13000.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
，是目前国际公认的免疫缺陷程度高的实验小鼠，非常适合人源细胞或组织移植，已经成功用于制备 CDX、PDX、人 PBMC 和 人 CD34+ HSC 免疫重建等模型，广泛应用在抗体药物或细胞治疗临床前评价中。使用 B-NDG 小鼠进行免疫重建和肿瘤造模后给药验证药效，实验结果如下： 图 2：（A）B-NDG 小鼠 T 细胞、B 细胞和 NK 细胞缺失；（B）B-NDG 小鼠 PBMC 重建模型验证 CD3/Claudin18.2 双抗药效；（C）B-NDG 小鼠 CD34+HSC 重建模型验证
张锋/曹云霞/司维/谭跃球等团队联合发现首个灵长类特异的弱畸精子症致病基因 SSX1
期刊《The American Journal of Human Genetics》上联合发表了题为 Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models 的论文成果。该研究通过全外显子测序、基因组拷贝数变异分析首次利用食蟹猴、树鼩两种动物模型，揭示了首个灵长类特异的弱畸精子症致病基因 SSX1。 该研究中
., Lafond, J. and Vaillancourt, C. (2012)】比如，在用qPCR分析非正常状态下（比如怀孕、疾病）胎盘里某些基因的表达稳定性，学者们采用18sRNA、GAPDH和b-actin这些为人们常用的内参基因来nomalization时，虽然能获得一些符合预期的结果，但是也有不少结果和预期设想背道而驰。实际上，我们许多lab的学生和技术员在抽提RNA只关注RNA的260/280比值，而忽视RNA的完整性。事实上，就胎盘组织而言，在样品处理过程中，大约有20%的RNA会严重降解
技术资料