- ¥900
- selleckchem
- 进口
- S5004
- 2025年08月10日
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- 文献和实验
- 技术资料
- 保存条件：
低温
- 库存：
大量
- 供应商：
上海善然生物科技有限公司
- 规格：
10mg
Pimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function. [1] Pimecrolimus prevents the release of cytokines and pro-inflammatory mediators from mast cells. Pimecrolimus binds to macrophilin-12, the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase. The pimecrolimus-macrophilin complex prevents the dephosphorylation of the cytoplasmic component of the nuclear factor of activated T cells by inhibiting the action of calcineurin. Pimecrolimus inhibits not only the transcription and synthesis of cytokines from mast cells, but also the release of preformed mediators serotonin and β-hexosaminidase by the inhibition of Fc∈-RI-mediated degranulation and secretion. Pimecrolimus treatment causes a strong down-regulation of the expression of mRNA for genes associated with the macrolactam target pathway and inflammation. [2]
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文献和实验相关实验
of a common Western European Caucasian HV1/HV2 mitotype was incorporated into a single base extension (SBE) assay. The assay was optimized for multiplex detection of sequence polymorphisms at positions 3010, 4793, 10211, 5004, 7028, 7202, 16519, 12858, 4580
with diverse molecules through the functionality transfer reaction and copper‐catalyzed azide‐alkyne cycloaddition reaction. Chem. Comm. 47:5004‐5006. Pasternak, A. and Wengel, J
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PimecrolimusS5004
¥900
