Beta-Amyloid (1-42), Ultra Pur

Product Name: Beta-Amyloid (1-42), Ultra Pure, HFIP

Catalog #: A-1163-2

Source: Recombinant. A DNA sequence encoding the human beta-amyloid
(1-42) sequence was expressed in E. coli.

Sequence: D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M VG G V V I A
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-
Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Molecular Mass: 4514.1

Peptide Purity: >97%

Counter Ion: HFIP treated

Supplied As: No salt, as HFIP desalts the sample.

Resuspension: Resuspend in 1 % NH4OH, at a concentration of 1 mg/ml. Sonicate for 30
seconds to 1 minute after it has gone into solution.
To bring it into your buffer: After resuspension, add 5x or 10x buffer stock
and water, to bring to 1x buffer.

Storage: –20℃

Description: Beta-amyloid peptide (Abeta), the major constituent of amyloid plaquesin the brains of Alzheimer’s patients, is thought to be the cause ofAlzheimer’s Disease (AD)1-3. AD is the most common neurodegenerativedisease and afflicts about 10% of the population over 604. Theabeta,HFIP is described in Stine, et. al.3.


References:
1) Yankner, BA, et. al., (1990) Science, 250: 279-282
2) Selkoe, D.J., (2001) Physiol. Rev, 81: 741-766
3) Stine, W.B. et. al., (2003) J. Biol. Chem, 278: 11612-11622
4) Frank, R.A., et. al., (2003) Neurobiology of Aging, 24: 521-536