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Merck-Sigma货号C0926现货(2-羟丙基)-β-
环糊精(别名:2-hydroxypropylether，Beta-cyclodextrin)上海睿安生物Merck密理博Sigma-Roche授权代理商19121878899- ￥5332.19
- Sigma-Aldrich
- made in USA
- C0926
- 2026年01月21日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
2-hydroxypropylether，Beta-cyclodextrin
- CAS号：
128446-35-5
- 保质期：
1年
- 保存条件：
Room Temperature
- 库存：
10⁺瓶
- 供应商：
上海睿安生物19121878899
- 规格：
5g/瓶
Merck-Sigma货号C0926-5g现货(2-羟丙基)-β-环糊精(别名:2-hydroxypropylether，Beta-cyclodextrin)上海睿安生物Merck密理博Sigma-Roche授权代理商19121878899
Merck-Sigma货号C0926-10g现货(2-羟丙基)-β-环糊精(别名:2-hydroxypropylether，Beta-cyclodextrin)上海睿安生物Merck密理博Sigma-Roche授权代理商19121878899
(2-羟丙基)-β-环糊精
powder,BioReagent,suitable for cell culture
别名:2-hydroxypropylether,Beta-cyclodextrin
说明
Application
亲脂性药物的溶解度随着水溶液中的羟丙基-β-环糊精（HBC）浓度线性增加，这是因为HBC与药物形成了复合物。这种客体-宿主型复合物在药物与HBC的非极性空穴间形成，导致溶解度增强。 可以将溶液冻干以产生易溶的粉末。 对家兔和小鼠无毒性。
General description
环糊精是由6、7或8个吡喃葡萄糖单元组成的环状低聚糖，通常分别称为α-、β-或γ-环糊精。这些化合物具有刚性环形结构，使其成为天然的络合剂。这些化合物的相邻吡喃葡萄糖单元的C2-和C3-羟基之间易于形成分子内氢键，使其独特结构具有稳定性。该分子具有圆环形状，其C2-和C3-羟基位于较大开口端周围，反应性更强的C6-羟基排列在较小开口端周围。与氢键合C2-和C3-羟基相对的C6-羟基排列迫使氧键在空腔内紧密靠近，产生一个富电子的疏水内部。该疏水性空腔的大小是形成环糊精的吡喃葡萄糖单元数的函数。
天然环糊精的溶解度非常低。在20世纪60年代后期，人们发现2、3和6羟基位置的化学取代能大大增加溶解度。大多数化学改性环糊精能够在水中达到50% (w/v)的浓度。
空腔大小是决定使用哪种环糊精进行络合的主要因素。β-环糊精或β-吡喃葡萄糖单元化合物的空腔直径非常适合用于与激素、维生素以及许多组织和细胞培养常用化合物大小相近的分子。因此，β-环糊精最常被用作络合剂。
天然环糊精的溶解度非常低。在20世纪60年代后期，人们发现2、3和6羟基位置的化学取代能大大增加溶解度。大多数化学改性环糊精能够在水中达到50% (w/v)的浓度。
空腔大小是决定使用哪种环糊精进行络合的主要因素。β-环糊精或β-吡喃葡萄糖单元化合物的空腔直径非常适合用于与激素、维生素以及许多组织和细胞培养常用化合物大小相近的分子。因此，β-环糊精最常被用作络合剂。
Preparation Note
溶液可在4°C下储存数月。固体应在室温下密封保存。
同行评审论文(部分:文献)
A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice.
Nicolas Schall et al.
Frontiers in pharmacology, 12, 752194-752194 (2021-11-09)
Dysregulation of CXCL12/SDF-1-CXCR4/CD184 signaling is associated with inflammatory diseases and notably with systemic lupus erythematosus. Issued from the lead molecule chalcone-4, the first neutraligand of the CXCL12 chemokine, LIT-927 was recently described as a potent analogue with improved solubility and
Transcriptome of HPβCD-treated Niemann-Pick disease type C1 cells highlights GPNMB as a biomarker for therapeutics.
Jorge L Rodriguez-Gil et al.
Human molecular genetics, 30(24), 2456-2468 (2021-07-24)
The rare, fatal neurodegenerative disorder Niemann-Pick disease type C1 (NPC1) arises from lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurological degeneration and premature death. The timing and severity of NPC1 clinical presentation
Regulatory Role of Orexin in the Antistress Effect of "Press Tack Needle" Acupuncture Treatment.
Aki Fujiwara et al.
Healthcare (Basel, Switzerland), 9(5) (2021-05-01)
The aim of this research was to investigate the antistress effect of press tack needle (PTN) acupuncture treatment using rats with social isolation stress (SIS). Rats were divided into non-stress group (Grouped+sham), stress group (SIS+sham), and PTN-treated SIS group (SIS+PTN).
The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.
T L Yaksh et al.
Life sciences, 48(7), 623-633 (1991-01-01)
The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or
Cyclodextrins.
Valentino J Stella et al.
Toxicologic pathology, 36(1), 30-42 (2008-03-14)
beta-cyclodextrin (beta-CD) and other cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs; however, some are nephrotoxic when administered parenterally. A number of workers have attempted to identify, prepare, and evaluate various CD derivatives with superior inclusion complexation and maximal
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文献和实验该产品被引用文献
Merck-Sigma货号C0926-5g现货(2-羟丙基)-β-环糊精(别名:2-hydroxypropylether，Beta-cyclodextrin)上海睿安生物Merck密理博Sigma-Roche授权代理商19121878899
Merck-Sigma货号C0926-10g现货(2-羟丙基)-β-环糊精(别名:2-hydroxypropylether，Beta-cyclodextrin)上海睿安生物Merck密理博Sigma-Roche授权代理商19121878899
(2-羟丙基)-β-环糊精
powder,BioReagent,suitable for cell culture
别名:2-hydroxypropylether,Beta-cyclodextrin
说明
Application
亲脂性药物的溶解度随着水溶液中的羟丙基-β-环糊精（HBC）浓度线性增加，这是因为HBC与药物形成了复合物。这种客体-宿主型复合物在药物与HBC的非极性空穴间形成，导致溶解度增强。 可以将溶液冻干以产生易溶的粉末。 对家兔和小鼠无毒性。
General description
环糊精是由6、7或8个吡喃葡萄糖单元组成的环状低聚糖，通常分别称为α-、β-或γ-环糊精。这些化合物具有刚性环形结构，使其成为天然的络合剂。这些化合物的相邻吡喃葡萄糖单元的C2-和C3-羟基之间易于形成分子内氢键，使其独特结构具有稳定性。该分子具有圆环形状，其C2-和C3-羟基位于较大开口端周围，反应性更强的C6-羟基排列在较小开口端周围。与氢键合C2-和C3-羟基相对的C6-羟基排列迫使氧键在空腔内紧密靠近，产生一个富电子的疏水内部。该疏水性空腔的大小是形成环糊精的吡喃葡萄糖单元数的函数。
天然环糊精的溶解度非常低。在20世纪60年代后期，人们发现2、3和6羟基位置的化学取代能大大增加溶解度。大多数化学改性环糊精能够在水中达到50% (w/v)的浓度。
空腔大小是决定使用哪种环糊精进行络合的主要因素。β-环糊精或β-吡喃葡萄糖单元化合物的空腔直径非常适合用于与激素、维生素以及许多组织和细胞培养常用化合物大小相近的分子。因此，β-环糊精最常被用作络合剂。
天然环糊精的溶解度非常低。在20世纪60年代后期，人们发现2、3和6羟基位置的化学取代能大大增加溶解度。大多数化学改性环糊精能够在水中达到50% (w/v)的浓度。
空腔大小是决定使用哪种环糊精进行络合的主要因素。β-环糊精或β-吡喃葡萄糖单元化合物的空腔直径非常适合用于与激素、维生素以及许多组织和细胞培养常用化合物大小相近的分子。因此，β-环糊精最常被用作络合剂。
Preparation Note
溶液可在4°C下储存数月。固体应在室温下密封保存。
同行评审论文(部分:文献)
A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice.
Nicolas Schall et al.
Frontiers in pharmacology, 12, 752194-752194 (2021-11-09)
Dysregulation of CXCL12/SDF-1-CXCR4/CD184 signaling is associated with inflammatory diseases and notably with systemic lupus erythematosus. Issued from the lead molecule chalcone-4, the first neutraligand of the CXCL12 chemokine, LIT-927 was recently described as a potent analogue with improved solubility and
Transcriptome of HPβCD-treated Niemann-Pick disease type C1 cells highlights GPNMB as a biomarker for therapeutics.
Jorge L Rodriguez-Gil et al.
Human molecular genetics, 30(24), 2456-2468 (2021-07-24)
The rare, fatal neurodegenerative disorder Niemann-Pick disease type C1 (NPC1) arises from lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurological degeneration and premature death. The timing and severity of NPC1 clinical presentation
Regulatory Role of Orexin in the Antistress Effect of "Press Tack Needle" Acupuncture Treatment.
Aki Fujiwara et al.
Healthcare (Basel, Switzerland), 9(5) (2021-05-01)
The aim of this research was to investigate the antistress effect of press tack needle (PTN) acupuncture treatment using rats with social isolation stress (SIS). Rats were divided into non-stress group (Grouped+sham), stress group (SIS+sham), and PTN-treated SIS group (SIS+PTN).
The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.
T L Yaksh et al.
Life sciences, 48(7), 623-633 (1991-01-01)
The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or
Cyclodextrins.
Valentino J Stella et al.
Toxicologic pathology, 36(1), 30-42 (2008-03-14)
beta-cyclodextrin (beta-CD) and other cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs; however, some are nephrotoxic when administered parenterally. A number of workers have attempted to identify, prepare, and evaluate various CD derivatives with superior inclusion complexation and maximal
文献支持
Merck-Sigma货号C0926现货(2-羟丙基)-β-环糊精(别名:2-hydroxypropylether，Beta-cyclodextrin)上海睿安生物Merck密理博Sigma-Roche授权代理商19121878899
￥5332.19
