- ¥1512.81
- sigma
- 进口
- S4317-5MG
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
低温
- 库存：
现货
- 供应商：
上海善然生物科技有限公司
- 规格：
5MG
Biochem/physiol Actions
Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.
SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility.4,5,6 It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.5
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Application
SB-431542 was used to study the correlation of platelet-derived growth factor receptor B expression and TGF-β pathway activation in colorectal tumor cells.1 It was used to study the role of TGF-β signaling in modulation of extracellular matrix2 and myoblast differentiation.3
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
性质
Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, Diversification Ready Pharma-Developed Compounds,
GlaxoSmithKline, Kinase/Phosphatase Biology, S, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, TGF-β Inhibitors, Transforming Growth Factor-β (TGF-β) and Superfamily, Transforming Growth Factor-β Type I Receptor Kinase (ALK5), Tyrosine Kinase-Like Biology, Tyrosine Kinase-Like Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
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assay ≥98% (HPLC)
form powder
solubility DMSO: soluble10 mg/mL
H2O: insoluble
originator GlaxoSmithKline
storage temp. −20°C
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文献和实验【求助】SB-431542 这个阻断剂用于阻断大鼠TGF通路 剂量如何掌握? 谢谢
张华高伟忠520 :o) 一顿饭 你应该查查文献可以看到吧，老大？ 就算查到了，不同的实验室或许条件不一样，我还是建议你用比如用5uM,10uM,20uM,50uM,100uM做个梯度，然后用WB检测阻断情况。选择完全阻断最小的剂量做你后面的实验。因为剂量越大，非特异性阻断作用越强，而你得到的数据说服力越小。 如果需要可PM我，我有一些关于阻滞剂使用的文献，蛮不错。
年后我看了这个帖子，发现两位前辈还是没找到啊。。。 taoist_zc SB431542 本文由丁香园论坛提供，想了解更多有用的、有意思的前沿资讯以及酷炫的实验方法的你，都可以成为师兄的好伙伴 师兄微信号：shixiongcoming
10 nM 10 nM 10 nM - - - - SB431542 - - - - 100 μM - - - - - - - - - ITS 1% 1% 1% 1% 1% 1% 1% 1% 1% - 1% 1% 1% 1% β-mercaptoethanol 90μM 90μM 90μM 90μM
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