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- 2025年07月12日
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- 保存条件：
-20℃
- 克隆性：
单克隆
- 抗体名：
Tumor Protein P53 (TP53) (AA 46-55) 抗体
- 规格：
0.1ml/0.2ml
Tumor Protein P53 (TP53)
别名 tp53, p53, TP53, Tp53, bbl, bfy, bhy, p44, TpMs, BCC7, LFS1, P53, TRP53, Trp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919
抗原表位
其他选择 AA 46-55
适用
其他选择 人
宿主
其他选择 小鼠
克隆类型 (克隆位点)
单克隆 (Pab 1801)
标记
其他选择 非结合性
应用范围
其他选择 免疫沉淀（IP）, Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), 免疫组织化学石蜡技术（IHC-P）
Pubmed 4个引用可参考
规格 0.1 mg
发货至 中国 (更改)
发货时间 29至35个工作日
产品编号 yb180578
产品细节Tumor Protein P53 (TP53) (AA 46-55) 抗体
免疫原 p53 beta Galactosidase fusion protein. Remarks: Mol. Wt. of Antigen: 53 kDa
克隆位点 Pab 1801
亚型 IgG1
特异性 This p53 antibody reacts with mutant as well as wild form of p53.
无交叉反应 小鼠
交叉反应 （详细） Species reactivity (tested):Human.
产品特性 Synonyms: Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13
纯化方法 Affinity Chromatography on Protein A.
目标详细情况 Tumor Protein P53 (TP53) (AA 46-55) 抗体
别名 p53 (TP53)
背景 P53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNAPK at Ser15, the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. p53 is phosphorylated at Ser6 and Ser9 by ck1d and ck1e both in vitro and in vivo. Phosphorylation of p53 at Ser46 is important in regulating the ability of p53 to induce apoptosis. In vivo phosphorylation of p53 at Ser33 by cdk7/cyclin H and in response to UV irradiation has been observed.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
基因ID 7157
UniProt P04637
使用细节Tumor Protein P53 (TP53) (AA 46-55) 抗体
应用备注 Western Blot. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理Tumor Protein P53 (TP53) (AA 46-55) 抗体
浓度 1.0 mg/mL
缓冲液 PBS containing 0.09 % Sodium Azide as preservative.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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文献和实验Interaction of p53 with the Adenovirus E1B-55 kDa Protein
The E1B-55 kDa oncoprotein of adenovirus type 5 targets the tumor suppressor protein p53. This includes four distinct activities: (i ) biochemical interaction of E1B-55 kDa with p53; (ii ) inhibition of p53-induced transcription; (iii
Science：直击肿瘤命门，Shibin Zhou 等开发靶向 TP53 突变的双特异性抗体
对突变型 p53 的药物被批准用于治疗含有这些突变的肿瘤患者。 2021 年 3 月 1 日，来自美国的 Bert Vogelstein, Sandra B. Gabelli 和 Shibin Zhou 团队研制出了一种靶向 TP53 突变基因的双特异性单链抗体（bispecific single-chain diabody，scDb）。这种双特异性抗体在体外和小鼠体内都能有效识别呈递新抗原的癌细胞，并激活 T 细胞，发挥抗肿瘤效应。 从理论上讲，这种双特异性抗体可以用来针对含有传统方法难以瞄准
Stability and Ubiquitination of the Tumor Suppressor Protein p53
The ubiquitin-dependent proteolysis pathway constitutes a major pathway in the cell for selective protein degradation. The covalent attachment of multiple ubiquitin molecules to lysine residues of a target protein serves to signal
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