Huntingtin (HTT) (AA 2703-2911) 抗体抗原
Huntingtin (HTT)
别名 HTT, hd, ZHD, CG9995, Dmel\\CG9995, HD, Hsap\\HD, Htt, dHtt, dhtt, SLC6A4, huntington, it15, htt, IT15, AI256365, C430023I11Rik, Hd, Hdh
抗原表位
其他选择 AA 2703-2911
适用
其他选择 人, 小鼠, 兔
宿主
其他选择 小鼠
克隆类型 (克隆位点)
单克隆 (HDC8A4)
标记
其他选择 非结合性
应用范围
其他选择 Immunohistochemistry (Frozen Sections) (IHC (fro)), 免疫沉淀(IP), Western Blotting (WB)
Pubmed 找到1个引用
规格 0.1 mg
发货至 中国 (更改)
发货时间 29至35个工作日
产品编号 yb119307
产品细节 Huntingtin (HTT) (AA 2703-2911) 抗体 免疫原 Recombinant protein corresponding to amino acids 2703 - 2911 of huntingtin
克隆位点 HDC8A4
亚型 IgG1
特异性 This antibody reacts with an epitope corresponding to the HDC region (2703 - 2911 amino acids) of the huntingtin protein. Clone HDC8A4 detects a 350KD band on western blots but also detects smaller degradation products of huntingtin. Clone HDC8A4 recognises both denatured and native huntingtin in human brain. The combined use of clone HDC8A4 (SM1662), HDB4E10 (SM1661) and HDA3E10 (SM1660) demonstrate that huntingtin is enriched in neuronal cells in the brain.
纯化方法 Affinity chromatography on Protein G
目标详细情况 Huntingtin (HTT) (AA 2703-2911) 抗体 别名 Huntingtin
背景 Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain. The huntingtin gene product is expressed at similar levels in patients and controls, which suggests that the expansion of the polyglutamine repeat induces a toxic gain of function perhaps through interactions with other cellular proteins. Using yeast two-hybrid system, HAP1 (huntingtin associated protein 1) has been identified, that associates with huntingtin protein. The In vitro data suggest that the association between HAP1 and huntingtin is enhanced by increasing length of glutamine repeat.Synonyms: HD, HTT, Huntington Disease Protein, IT15
基因ID 3064
NCBI登录号 NP_002102
UniProt P42858
研究领域 Neurology, Virology
使用细节 Huntingtin (HTT) (AA 2703-2911) 抗体 应用备注 Immunohistochemistry on frozen sections. Immunoprecipitation. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理Huntingtin (HTT) (AA 2703-2911) 抗体 浓度 1.0 mg/mL
缓冲液 PBS containing 0.09 % Sodium Azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.