peptide corresponding to a sequence at the N-terminus of human CIAS1.
亚型:
Rabbit Polyclonal IgG
形态:
液态
保存条件:
保存于-20℃
克隆性:
多克隆
标记物:
无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)
适应物种:
Hu,Mo,Rat
保质期:
按说明书条件可保存1-2年
抗原来源:
见详细说明资料
目录编号:
PL0402307
级别:
超纯
库存:
大量
供应商:
华拓生物
宿主:
Rabbit
应用范围:
WB: 1:100-500 IHC: 1:500-1000
浓度:
1mg/ml
靶点:
NLRP3
抗体英文名:
NLRP3 Antibody
抗体名:
NLRP3抗体
规格:
0.1ml
NLRP3 Antibody
Cat#:PL0402307
Isotype:Rabbit Polyclonal IgG
Immunogen:peptide corresponding to a sequence at the N-terminus of human CIAS1.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
NLRP3(NLR FAMILY, PYRIN DOMAIN-CONTAINING 3), also known as CIAS1, CRYOPYRIN, NALP3 or PYPAF1, is a protein that in humans is encoded by the NLRP3(NOD-like receptor family, pryin domain containing 3) gene. The NLRP3 gene encodes a pyrin-like protein expressed predominantly in peripheral blood leukocytes. And the NLRP3 gene is mapped on 1q44. NLRP3 interacts with apoptosis-associated speck-like protein containing a CARD(ASC). The encoded protein may play a role in the regulation of inflammation and apoptosis. Mutation of the NALP3 nucleotide-binding domain reduced ATP binding, CASP1 activation, IL1B production, cell death, macromolecular complex formation, self-association, and association with ASC. Consistent with an essential role for Nlrp3 inflammasomes in antifungal immunity, Gross et al.showed that Nlrp3-deficient mice are hypersusceptible to C. albicans infection. Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells.
Alternate Names:
AGTAVPRL antibody;AII/AVP antibody;Angiotensin/vasopressin receptor AII/AVP like antibody;Angiotensin/vasopressin receptor AII/AVP-like antibody;C1orf7 antibody;Caterpiller protein 1.1 antibody;CIAS1 antibody;CLR1.1 antibody;Cold autoinflammatory syndrome 1 antibody;Cold autoinflammatory syndrome 1 protein antibody;Cryopyrin antibody;Familial cold autoinflammatory syndrome antibody.
Specificity Reaction:Hu,Mo,Rat
Application Notes:WB: 1:100-500 IHC: 1:500-1000
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.