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Ecadherin binding protein E7 A

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  • ¥2400
  • PLLABS已认证
  • 加拿大
  • PL0306501
  • 2025年07月06日
  • WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:50-200
  • Rabbit
  • Hu, Mo, Rat, Dog, Pig, Cow, Hor
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Peptide derived from human CBLL1/Ecadherin binding protein E7.

    • 亚型

      Rabbit Polyclonal IgG

    • 形态

      液态

    • 保存条件

      保存于-20℃

    • 克隆性

      多克隆

    • 标记物

      无标记(PLlabs可供应生物素、酶、荧光素标记的抗体)

    • 适应物种

      Hu, Mo, Rat, Dog, Pig, Cow, Hor

    • 保质期

      按说明书条件可保存1-2年

    • 抗原来源

      见详细说明资料

    • 目录编号

      PL0306501

    • 级别

      超纯

    • 库存

      大量

    • 供应商

      华拓生物

    • 宿主

      Rabbit

    • 应用范围

      WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:50-200

    • 浓度

      1mg/ml

    • 靶点

      Ecadherin binding protein E7

    • 抗体英文名

      Ecadherin binding protein E7 Antibody

    • 抗体名

      上皮钙粘附分子结合蛋白E7

    • 规格

      0.1ml

    产品细节图片1
    Ecadherin binding protein E7 Antibody
    Cat#:PL0306501
    Isotype:Rabbit Polyclonal IgG
    Immunogen:Peptide derived from human CBLL1/Ecadherin binding protein E7.
    Purification: Immunogen affinity purified

    Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)

    Background:
    CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts.
    Alternate Names:
    c-Cbl-like protein 1; CasBrM (murine) ecotropic retroviral transforming sequencelike 1; Casitas B-lineage lymphoma transforming sequence-like protein 1; Casitas B-lineage lymphoma-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; cbll1; E3 ubiquitin-protein ligase Hakai; Ecadherin binding protein E7; HAKAI; HAKAI_HUMAN; RING finger protein 188; RNF188; MGC163401.
    Specificity Reaction:Hu, Mo, Rat, Dog, Pig, Cow, Hor
    Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:50-200
    Storage :
    Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.

    This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
    PLlabs公司可供应相应抗体的生物素、辣根过氧化物酶、荧光素(FITC、PE、 CY3、 CY5、 CY7、 PE- CY3/5/7)标记抗体,欢迎大家咨询订购。

    产品细节图片2 产品细节图片3 产品细节图片4
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    图标文献和实验
    相关实验
    • ANTIBODY BINDING TO PROTEIN A AND PROTEIN G

      2c + ++ Sources of information: Akerstrom, B., Brodin, T., Reis, K., and Bjorck, L. 1985. Protein G: A powerful tool for binding and detection of monoclonal and polyclonal antibodies. J. Immunol. 135:2589-2592. Akerstrom, B. and Bjorck, L. 1986

    • Epitope Mapping: Identiflcation of Antibody- Binding Sites on Protein Antigens

      An epitope can be simply defined as that part of an antigen involved in its recogmtion by an antibody In the case of protein antigens, an epitope would consist of a group of mdlvidual ammo-acid side-chains close together on the protein surface

    • Analysis of E7/Rb Associations

      . In this chapter, we describe two methods to measure the efficiency of the E7 proteins from different HPV types in neutralizing the pRb functions. The first one, the plate-binding assay, allows the determination of the pRb binding affinity of E7 proteins

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