- 询价
- 沪震生物
- 中国/美国
- hz084Cp01
- 2025年07月15日
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- 文献和实验
- 技术资料
- 保存条件：
-20℃
- 保质期：
12个月
- 英文名：
Recombinant Leptin (LEP)
- 库存：
100
- 供应商：
上海沪震
FOR IN VITRO AND RESEARCH USE ONLY, NOT FOR USE IN CLINICAL DIAGNOSTIC PROCEDURES!
Organism species Capra hircus; Caprine (Goat)
Product No. RPA084Cp01
Source Prokaryotic expression
Host E.coli
Purity > 95%
UOM 50ug
Predicted Molecular Mass n/a
Applications SDS-PAGE; WB; ELISA; IP.
Endotoxin Level <1.0EU per 1µg (determined by the LAL method)
Residues n/a
Formulation Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
USAGE
Reconstitute in sterile PBS, pH7.2-pH7.4.
STORAGE AND STABILITY
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8oC for one month. Aliquot and store at -80oC for 12 months.
瘦素(LEP)重组蛋白Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
About the MARKER (complimentary)
Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
瘦素(LEP)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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01 靶点：FGF21 应用：肥胖、2型糖尿病等代谢疾病的潜在治疗靶点来源：FGF21 synergizes with leptin to counteract obessity related metabolic comorbidities by reversing hepatic leptin resistance.Cell Metab,2026 Sep 1 香港大学徐爱民团队近期在Cell Metabolism发表了一篇研究，开发了长效FGF21与瘦素双
载体，非常适合用于评估基于细胞或免疫疗法的糖尿病治疗策略。 NPG小鼠+STZ数据展示 图5. STZ诱导NPG小鼠I型糖尿病模型造模与验证 由图可知，NPG小鼠经过STZ诱导后，空腹血糖长期处于高数值范围（空腹血糖值均稳定在11.1mmol/l以上），表明糖尿病模型已成功建立，且处于血糖水平较高的稳定高血糖状态。 其他可提供模型：瘦素基因 (Lep)突变的ob/ob小鼠、瘦素受体基因 (Lepr)突变的db/db小鼠 05｜特色高脂血症/动脉
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