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文献和实验Isolation of Human Monoclonal Antibodies Using Guided Selection with Mouse Monoclonal Antibodies
Repertoires of antibody (Ab) V genes derived from nonimmunized human donors (1 ) or made synthetically (2 3 ) have been cloned for display on filamentous bacteriophage as either scFvs or Fabs fused to the minor phage coat protein (pIII
Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation
. Most of the side effects observed with first-generation murine (mouse or rat) antibodies have been successfully overcome with the advent of humanized (chimeric or CDR-grafted) and more recently fully human antibodies. Our aim is to review the major steps in the development
Chimerization of a Monoclonal Antibody for Treating Hodgkin's Lymphoma
of the immunotoxin (6 ). In order to fully preserve the specificity of Ber-H2 and to overcome the aforementioned disadvantages, we have generated a chimeric mouse/human antibody.
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