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文献和实验Detection of DNA-Dependent Protein Kinase in Extracts from Human and Rodent Cells
The DNA-dependent protein kinase, DNA-PK, is required for DNA double-strand break repair and V(D)J recombination (1 –3 ). DNA-PK is composed of a large catalytic subunit of approx 460 kDa (DNA-PKcs) and a heterodimeric DNA targeting subunit
DNA-Dependent Protein Kinase in Apoptosis
target proteins, one of which is the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). The antiapoptotic factor Bcl-xL can sequester cytochrome C and inhibit the formation of the caspase-9-Apaf-1 complex effectively blocking apoptosis
Cyclin-Dependent Kinase 5 (Cdk5): Preparation and Measurement of Kinase Activity
Cyclin-dependent kinase 5 (Cdk5) is a versatile protein kinase that plays a role in a variety of neuronal activities including neuronal migration during brain development, synaptic activities in mature neurons, and neuronal
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