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- 克隆性：
单克隆
- 抗体英文名：
Anti-PSAP/PAP(Prosta
- 抗体名：
前列腺酸性磷酸酶抗体
前列腺酸性磷酸酶抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
前列腺酸性磷酸酶抗体产品介绍
表达在正常的前列腺、前列腺增生和前列腺肿瘤中。
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D, which are similar to each other and are sphingolipid hydrolase activator proteins. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in PSAP gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy.
mol wt:58kDa
Other Aliases:
Other Aliases:
Prostate Specific Acidic Phosphatase; GLBA; Proactivator polypeptide; Proactivator polypeptide precursor; Prosaposin (sphingolipid activator protein 1); prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy); SAP1; Saposin A; Saposin B; Saposin B Val; Saposin C; Saposin D; Saposins
前列腺酸性磷酸酶抗体
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D, which are similar to each other and are sphingolipid hydrolase activator proteins. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in PSAP gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy.
mol wt:58kDa
Other Aliases:
Other Aliases:
Prostate Specific Acidic Phosphatase; GLBA; Proactivator polypeptide; Proactivator polypeptide precursor; Prosaposin (sphingolipid activator protein 1); prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy); SAP1; Saposin A; Saposin B; Saposin B Val; Saposin C; Saposin D; Saposins
前列腺酸性磷酸酶抗体
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文献和实验相关实验
非血浆特异酶 在血浆中浓度很低，且无功能，又可分为两种。 （1）分泌酶：指来源于外分泌腺的酶，如胰淀粉酶、胰脂肪酶、胰蛋白酶、胃蛋白酶和前列腺酸性磷酸酶等。它们在血液中也以失活状态存在，不发生催化作用。在血液中的浓度和其分泌腺体的功能活动和疾病有关，医学教|育网搜集整理例如，急性胰腺炎时，血淀粉酶就会升高。 （2）代谢酶：指存在于细胞内，参与细胞内新陈代谢的酶，它们随细胞的不断更新和破坏经常释出极少量进入血液，细胞内、外浓度差异悬殊，在血液中不发挥催化作用。病理
15-3、CA19-9、PSA、SCC等），酶类（如神经元特异性烯醇化酶NSE、前列腺酸性磷酸酶PAP等），激素（hCG等），类固醇激素受体（如雌激素和孕酮受体等），单克隆免疫球蛋白和癌基因表达蛋白。
检测方法 对于探针和靶序列杂交之后的检测，我们通常使用碱性磷酸酶（AP）耦联的抗体，采用显色法或化学发光法检测。在碱性磷酸酶的底物中，我们使用CDP-Star或CSPD用于化学发光法检测，NBT/BCIP用于显色法检测。同时，对于膜杂交中的化学发光信号的检测，建议使用Lumi-Film以获得最理想的信号。 检测底物 即用型CDP
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前列腺酸性磷酸酶抗体
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