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- 详细信息
- 技术资料
- 克隆性:
单克隆
- 抗体英文名:
Anti-Notch3(Neurogen
- 抗体名:
跨膜受体蛋白Notch-3抗体
跨膜受体蛋白Notch-3抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
跨膜受体蛋白Notch-3抗体产品介绍
Notch3是保守的Ⅰ型跨膜受体,Notch3信号通路在机体发育过程中调控细胞生长、分化和凋亡等多种重要生物学过程.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot).
跨膜受体蛋白Notch-3抗体
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot).
跨膜受体蛋白Notch-3抗体
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跨膜受体蛋白Notch-3抗体
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