- 询价
- 钰博生物
- 进口/国产
- YB-0802R
- 2025年07月09日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 克隆性：
单克隆
- 抗体英文名：
Anti-BRCA1(Breast ca
- 抗体名：
乳腺癌易感基因1抗体(人)
bs-0803R 用于检测mo, rat的BRCA1
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
mol wt:205kDa
Other Aliases:
BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53
yb-1099R Calpain 1钙蛋白酶1抗体
yb-0095R Calponin 1钙调节蛋白-1抗体
yb-0151R Caspase-6 (CT)半胱胺酸蛋白酶蛋白-6抗体（C端）
yb-0571R Cyclin A2周期素A2抗体
yb-0564R CaMK2 alpha钙/钙调素依赖蛋白激酶2α抗体
yb-0541R CaMK2 beta gamma delta钙/钙调素依赖蛋白激酶2b/2γ抗体
yb-1078R Exportin-2细胞凋亡敏感性基因抗体
yb-0169R Caspase-1 P10天冬氨酸-胱氨酸特异性蛋白酶家族抗体
yb-0092R Caspase-10半胱胺酸蛋白酶-10抗体
yb-1105R Caspase-12半胱胺酸蛋白酶蛋白-12抗体
yb-0053R Caspase-13 + 4半胱胺酸蛋白酶蛋白-13抗体
yb-0527R CD10CD10抗体
yb-0579R CD105CD105抗体
yb-0672R c-Kit干细胞生长因子受体/细胞表面分化抗原抗体
yb-6470R CLCN2氯离子通道蛋白2抗体
yb-1060R Cytokeratin 5细胞角蛋白5抗体
yb-1106R CK8细胞角蛋白8抗体
yb-0548R MERTKc-mer原癌基因酪氨酸激酶抗体
yb-0709R Collagen IIⅡ型胶原α1蛋白/软骨钙素抗体
yb-0549R Collagen IIIⅢ型胶原蛋白/胶原蛋白3/3型胶原蛋白抗体
yb-0806R Collagen IVIV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体
yb-0582R Cyclooxygenase 1前列腺素氧化环化酶1抗体
yb-0578R Collagen IⅠ型胶原抗体
yb-0552R Collagen VⅤ型胶原抗体
yb-0554R Collagen XⅩ型胶原抗体
yb-1686R Cyclin F周期素F抗体
yb-9127R Cullin 7泛素连接酶CUL7蛋白抗体
yb-9125R COPS2甲状腺受体相互作用蛋白15抗体
yb-9120R COPS6信号转导蛋白亚基6抗体
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验与基因稳定性有关的基因 与基因 稳定性有关的基因主要是乳腺癌易感基因―1(BRCA―1)，它位于17q21，是熟知的乳腺癌易感基因。用反义核酸技术抑制BRCAl的表达，可增加正常及恶性乳腺细胞的增殖，而野生型BRCAl的过度表达可抑制MCF―7等乳腺癌细胞在小鼠体内的成瘤能力。在近一半的遗传性乳腺肿瘤中发现BRCAl的遗传性突变。与其他抑癌基因不同的是，尽管在乳腺癌及卵巢癌中BRCAl基因发生LOH的频率很高，但其体细胞突变很少见。既然在散发性乳腺癌中
文献速递：个性化循环肿瘤 DNA 可成为免疫治疗疗效新型biomarker
(IF=23.5/中科院一区)杂志上发表的题为 Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab的研究成果发现肿瘤释放到血液中的循环肿瘤DNA（ctDNA）的水平变化能够预测患者的免疫治疗疗效[1]。这项发现无疑为免疫治疗打开了新的突破口。 该研究团队发起了一项包括头颈部鳞状细胞癌 (SCCHN)、三阴性乳腺癌
三句话读懂一篇 CNS，酗酒背后的机制，环境-基因互作诱导肿瘤发生，Cas9 时钟...
Cancer Risk Genes — Association Analysis in More than 113,000 Women，该研究以应用由 34 个推测的易感基因构成的基因面板，对 60,466 例乳腺癌女性患者和 53,461 例对照女性的样本进行了测序，筛选出如 ATM、BRCA1、BRCA2、CHEK2 和 PALB2 等数个预测乳腺癌风险最有用的基因，这些结果能有效用于备孕人士的遗传咨询。乳腺癌作为全球第一大癌症，女性朋友们定要多加防范，做好癌症筛查！ 图片来源：站酷海洛
技术资料暂无技术资料 索取技术资料
