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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CP-4126; CO-101; Gemcitabine 5'-elaidate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
210829-30-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1219.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥342.0 |
| 规格： | 5 mg | 产品价格： | ￥1050.0 |
| 规格： | 10 mg | 产品价格： | ￥1450.0 |
| 规格： | 50 mg | 产品价格： | ￥4450.0 |
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Gemcitabine elaidate
CAS No. : 210829-30-4
MCE 国际站：Gemcitabine elaidate
产品活性：Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前体。Gemcitabine elaidate 通过酯酶转化为 Gemcitabine 以被磷酸化。Gemcitabine elaidate 具有抗肿瘤活性。
研究领域：Cell Cycle/DNA Damage | Autophagy | Apoptosis
作用靶点：Nucleoside Antimetabolite/Analog | Autophagy | Apoptosis
In Vitro: Gemcitabine elaidate (0.2 nM-1 mM; 72 h) inhibits the growth of gemcitabine sensitive and resistant cells, with IC50s of 0.0033, 16.0, 0.0042, 13.0, 0.0015, 0.03, 0.0025, 91, 0.0040, 0.0077, 0.028, and 0.088 μM for L1210/L5, L4A6, BCLO, Bara-C, C26-A, C26-G, A2780, AG6000, THX, LOX, MOLT4 and MOLT4/C8 cells, respectively.
Gemcitabine elaidate (0.5 nM-1 μM; 72 h) increases S phase accumulation and dose-dependent cell kill in A549 and WiDR cells.
In Vivo: Gemcitabine elaidate (25-120 mg/kg; i.p. every 3 days for 5 doses) inhibits the solid tumor xenografts growth of non-small cell lung cancer (EKVX), non-classifiable sarcoma (MHMX), fibrous histiocytoma (TAX II-1), malignant melanoma (THX), prostate cancer (CRL-1435), pancreatic cancer (PANC-1).
Gemcitabine elaidate (10-20 mg/kg; p.o. every 3 days for 5 doses) shows acceptable toxicity and significant antitumor activity in the colon cancer xenograft Co6044 bearing mice.
Gemcitabine elaidate (p.o. once daily for 5 doses) shows a favorable toxicity and antitumor activity, while the dose of 15 mg/kg is highly toxic in the human colon cancer xenograft Co6044.
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文献和实验vaccination is of great interest in particular for the enhancement of antitumor, including “anti-self,” vaccination strategies to treat cancer. Here we describe the effect of Gemcitabine, a standard chemotherapeutic drug, on human and mouse regulatory T-cells
【进展|热点】Science:胰腺腺癌治疗新思路-CD40分子激活抗肿瘤细胞
the combination of an agonist CD40 antibody with gemcitabine chemotherapy in a small cohort of patients with surgically incurable PDA and observed tumor regressions in some patients. We reproduced this treatment effect in a genetically engineered mouse model
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