Naspm trihydrochloride,1049731

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Naspm trihydrochloride

CAS No. : 1049731-36-3

MCE 国际站：Naspm trihydrochloride

产品活性：Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) 是Joro蜘蛛毒素的合成类似物，是CP-AMPA受体拮抗剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: NASPM selectively suppresses the inwardly rectifying and Ca²⁺-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC₅₀ value of 0.33 µM. The blocking effect of NASPM on the Ca²⁺-permeable AMPA receptors is use and voltage-dependent.

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