BST-1 / CD157 / BST1抗体

BST-1 / CD157 / BST1抗体产品信息

免疫原 :
Recombinant human BST-1 protein ( Catalog#10060-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human BST-1 / CD157 ( rhBST-1; Catalog#10060-H08H; NP_004325.2; Met 1- Lys 292 ). Total IgG was purified by Protein A affinity chromatography.
BST-1 / CD157 / BST1抗体背景综述
Human CD157, also known as bone marrow sromal cell antigen 1 (BST-1), is a pleiotropic ectoenzyme which belongs to the CD38 family and to the growing number of leukocyte surface molecules known to act independently as both receptors and enzymes. As a 45-kDa surface glycoprotein with a GPI anchor, the CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties. CD157 shares several characteristics with CD38, including a similar amino acid sequence and enzymic functions. Both molecules are involved in the metabolism of NAD+, and the CD157 gene is synthenic on 4p15 with CD38, with which it also shares a unique genomic organization. Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell.
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