SLAMF1 / CD150 / SLAM抗体

SLAMF1 / CD150 / SLAM抗体产品信息

免疫原 :
Recombinant human CD150 protein ( Catalog#10837-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human SLAMF1 / CD150 ( rhSLAMF1 ; Catalog#10837-H08H ; NP_003028.1; Met 1- Pro 258 ). SLAMF1 specific IgG was purified by human SLAMF1 affinity chromatography.
SLAMF1 / CD150 / SLAM抗体背景综述
Signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phospho-glycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. It has a 77-residue cytoplasmic tail containing several tyrosines within motifs for Src-homology 2 (SH2)-domain binding sites, and interacts with SH2 domain protein 1A (SH2D1A) and with PTPN11. LAM is constitutively expressed on peripheral-blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of interferon γ (IFN-γ) in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.
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