CD16-2 / FCGR4抗体

CD16-2 / FCGR4抗体产品信息

免疫原 :
Recombinant mouse FCGR4 protein ( Catalog#50036-M08H )
Ig Type :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse FCGR4 ( rM FCGR4 ; Catalog#50036-M08H ; NP_653142.2 ; Met 1-Gln 203 ; ). FCGR4 specific IgG was purified by mouse FCGR4 affinity chromatography.
CD16-2 / FCGR4抗体 Background
Receptors for the Fc region of IgG (Fc γ Rs) constitute a subfamily of the Ig superfamily , and function in the activation or inhibition of immune responses. Based on close relationships in their extracellular domains, the Fc γ R have been divided into three classes designated as Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Human CD16 is encoded by two genes: Fc γ RIIIA and Fc γ RIIIB, and the newly described mouse FCGR4, also referred to as CD16-2, has been proposed to be the mouse homolog of human Fc γ RIIIA because of high sequence homology (60 % aa identity). FCGR4 is expressed in peripheral blood leukocytes, spleen, thymus, colon and intestine, and serves as an activating receptor for IgG2a and IgG2b via association with an ITAM bearing accessory protein. Although mouse FCGR4 functioned as a low-affinity IgE receptor for all IgE allotypes, ligation of FCGR4 by antigen-IgE(b) immune complexes promotes macrophage-mediated phagocytosis, presentation of antigen to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.
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