NTRK2 / Trk-B / TRKB抗体

NTRK2 / Trk-B / TRKB抗体产品信息

免疫原 :
Recombinant human Trk-B protein ( Catalog#10047-H08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human NTRK2 / Trk-B extracellular domain ( rh Trk-B; Catalog#10047-H08H; NP_001007098.1; Met 1- His 430 ). Trk-B specific IgG was purified by human Trk-B affinity chromatography
NTRK2 / Trk-B / TRKB抗体背景综述
TrkB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor exclusively expressed in neurons of the central nervous system. BDNF(brain-derived neurotrophic factor) exerts biological actions through its physiological receptor TrkB which leads to the initiation of intracellular signaling cascades and different biological responses in neurons. TRKB has two distinct binding regions for BDNF within the extracellular domain with high affinity. Upon neurotrophin binding, TrkB phosphorylates itself and the downstream molecular members of the related signal pathways. TrkB has been shown to play an important role in tumorigenesis and metastasis, and mutations in this gene are associated with obesity and mood disorders. Accordingly, BDNF/TrkB signaling is thought to be a potential therapeutic target for schizophrenia.
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