FGF1 / aFGF抗体

FGF1 / aFGF抗体产品信息

免疫原 :
Recombinant mouse aFGF protein ( Catalog#50179-MNAE )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, E.coli-derived, recombinant mouse aFGF ( rM aFGF ; Catalog#50179-MNAE ; NP_034327.1 ; Phe 16 - Asp 155 ). aFGF specific IgG was purified by mouse aFGF affinity chromatography.
FGF1 / aFGF抗体背景综述
Mouse acidic fibroblast growth factor (aFGF), also known as heparin-binding growth factor (HBGF-1) and FGF1, is a member of FGF family. FGF family members are involved in a variety of biological processes. FGF1 is considered to function in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis. This protein acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro and stimulates cell growth, migration, and differentiation. FGF1 binds to cell surface receptors with high affinity with the prerequisite association of FGF-acidic with heparan sulfate. The ligation subsequently initiates receptor dimerization, transphosphorylation, as well as internalization of receptor/FGF complexes, and thus aFGF is translocated across cellular membranes and transported to the nucleus. It has been demonstrated that PI 3-kinase activity is required both for transport of aFGF to the cytosol and to the nuclear fraction.
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